The Impact of PPARγGenetic Variants on IBD Susceptibility and IBD Disease Course
| Autor: | Jyrki J. Eloranta, Gerd A. Kullak-Ublick, Jessica Mwinyi, Christa Grete-Wenger |
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| Přispěvatelé: | University of Zurich, Kullak-Ublick, Gerd A |
| Rok vydání: | 2012 |
| Předmět: |
Article Subject
610 Medicine & health Single-nucleotide polymorphism Inflammatory bowel disease 03 medical and health sciences Exon 0302 clinical medicine Immune system Drug Discovery medicine 2736 Pharmacology (medical) Pharmacology (medical) Allele lcsh:QH301-705.5 Gene 030304 developmental biology Genetics 0303 health sciences business.industry 3002 Drug Discovery Haplotype medicine.disease digestive system diseases lcsh:Biology (General) Nuclear receptor 10199 Clinic for Clinical Pharmacology and Toxicology 10076 Center for Integrative Human Physiology 570 Life sciences biology 030211 gastroenterology & hepatology business Research Article |
| Zdroj: | Mwinyi, Jessica; Grete-Wenger, Christa; Eloranta, Jyrki J.; Kullak-Ublick, Gerd A. (2012). The Impact of PPARγ Genetic Variants on IBD Susceptibility and IBD Disease Course. PPAR Research, 2012, p. 349469. New York, N.Y.: Hindawi Publishing Corporation 10.1155/2012/349469 PPAR Research, Vol 2012 (2012) PPAR Research |
| ISSN: | 1687-4765 1687-4757 |
| Popis: | PPARγ is a nuclear receptor that regulates numerous pathways including cytokine expression and immune responses and plays an important role in controlling colon inflammation. We aimed at determining the occurringPPARγ SNPs, at predicting the haplotypes, and at determining the frequency outcome in inflammatory bowel disease (IBD) patients in comparison with healthy controls. We determined genetic variants in the coding exons and flanking intronic sequences of theNR1C3gene in 284 IBD patients and 194 controls and predictedNR1C3haplotypes via bioinformatic analysis. We investigated whether certainNR1C3variants are associated with susceptibility to IBD or its disease course. None of the detected 22NR1C3variants were associated with IBD. Two variants with allelic frequencies over 1% were included in haplotype/diplotype analyses. None of theNR3C1haplotypes showed association with IBD development or disease course. We conclude thatNR1C3haplotypes are not related to IBD susceptibility or IBD disease activity. |
| Databáze: | OpenAIRE |
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