Chronic consumption of the dietary polyphenol chrysin attenuates metabolic disease in fructose-fed rats
| Autor: | Cláudia G. Silva, Elisa Keating, Sara Andrade, Nelson Andrade, Luísa Guardão, Fátima Martel, Ilda Rodrigues, João Tiago Guimarães |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty medicine.medical_treatment Medicine (miscellaneous) 030209 endocrinology & metabolism Fructose Dietary Polyphenol Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Oral administration Internal medicine medicine Animals Chrysin Flavonoids Metabolic Syndrome 030109 nutrition & dietetics Nutrition and Dietetics business.industry Insulin Polyphenols medicine.disease Blood proteins Angiotensin II Diet Rats Disease Models Animal Endocrinology chemistry Metabolic syndrome business |
| Zdroj: | European journal of nutrition. 59(1) |
| ISSN: | 1436-6215 |
| Popis: | Metabolic syndrome (MS) is a major public health issue worldwide and fructose consumption has been associated with MS development. Recently, we showed that the dietary polyphenol chrysin is an effective inhibitor of fructose uptake by human intestinal epithelial cells. Therefore, our aim was to investigate if chrysin interferes with the development of MS induced by fructose in an animal model. Adult male Sprague–Dawley rats (220–310 g) were randomly divided into four groups: (A) tap water (control), (B) tap water and a daily dose of chrysin (100 mg/kg) by oral administration (chrysin) (C) 10% fructose in tap water (fructose), and (D) 10% fructose in tap water and a daily dose of chrysin (100 mg/kg) by oral administration (fructose + chrysin). All groups were fed ad libitum with standard laboratory chow diet and dietary manipulation lasted 18 weeks. Fructose-feeding for 18 weeks induced an increase in serum triacylglycerols, insulin and angiotensin II levels and in hepatic fibrosis and these changes did not occur in fructose + chrysin rats. Moreover, the increase in both systolic and diastolic blood pressure which was found in fructose-fed animals from week 14th onwards was not observed in fructose + chrysin animals. In contrast, the increase in energy consumption, liver/body, heart/body and right kidney/body weight ratios, serum proteins, serum leptin and liver triacylglycerols observed in fructose-fed rats was not affected by chrysin. Chrysin was able to protect against some of the MS features induced by fructose-feeding. |
| Databáze: | OpenAIRE |
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