Gut peptides and the microbiome: focus on ghrelin
Autor: | Harriët Schellekens, Natasha K Leeuwendaal, John F. Cryan |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Growth hormone secretagogue receptor 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Biology Gut flora digestive system 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Orexigenic Internal Medicine medicine gut peptides microbiota Humans Secretion Microbiome Nutrition and Dietetics digestive oral and skin physiology Peptide secretion biology.organism_classification Gastrointestinal Microbiome Gastrointestinal Tract appetite ghrelin Ghrelin metabolism GASTROINTESTINAL HORMONES: Edited by H. Christian Weber medicine.drug Hormone Signal Transduction |
Zdroj: | Current Opinion in Endocrinology, Diabetes, and Obesity |
ISSN: | 1752-2978 1752-296X |
Popis: | Purpose of review In this review, we present recent insights into the role of the gut microbiota on gastrointestinal (GI) peptide secretion and signalling, with a focus on the orexigenic hormone, ghrelin. Recent findings Evidence is accumulating suggesting that secretion of GI peptides is modulated by commensal bacteria present in our GI tract. Recent data shows that the gut microbiome impacts on ghrelinergic signalling through its metabolites, at the level of the ghrelin receptor (growth hormone secretagogue receptor) and highlights concomitant changes in circulating ghrelin levels with specific gut microbiota changes. However, the mechanisms by which the gut microbiota interacts with gut peptide secretion and signalling, including ghrelin, are still largely unknown. Summary The gut microbiota may directly or indirectly influence secretion of the orexigenic hormone, ghrelin, similar to the modulation of satiety inducing GI hormones. Although data demonstrating a role of the microbiota on ghrelinergic signalling is starting to emerge, future mechanistic studies are needed to understand the full impact of the microbiota-ghrelin axis on metabolism and central-regulated homeostatic and non-homeostatic controls of food intake. |
Databáze: | OpenAIRE |
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