The role of pattern recognition receptors in the innate recognition ofCandida albicans

Autor:	Yuan-Ying Jiang, Yan Wang, Nan-xin Zheng, Lan Yan, Dan-Dan Hu
Rok vydání:	2015
Předmět:	Microbiology (medical) Hypha Immunology Hyphae Reviews Virulence Single-nucleotide polymorphism Polymorphism Single Nucleotide Microbiology Mice Candida albicans Animals Humans Phagocytes Innate immune system Transition (genetics) biology Pattern recognition receptor Endothelial Cells Epithelial Cells Dendritic Cells biology.organism_classification Immunity Innate Corpus albicans Infectious Diseases Receptors Pattern Recognition Host-Pathogen Interactions Parasitology
Zdroj:	Virulence. 6:347-361
ISSN:	2150-5608 2150-5594
Popis:	Candida albicans is both a commensal microorganism in healthy individuals and a major fungal pathogen causing high mortality in immunocompromised patients. Yeast-hypha morphological transition is a well known virulence trait of C. albicans. Host innate immunity to C. albicans critically requires pattern recognition receptors (PRRs). In this review, we summarize the PRRs involved in the recognition of C. albicans in epithelial cells, endothelial cells, and phagocytic cells separately. We figure out the differential recognition of yeasts and hyphae, the findings on PRR-deficient mice, and the discoveries on human PRR-related single nucleotide polymorphisms (SNPs).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e088427c6ca0ee91ad55dc9154a4d6 https://doi.org/10.1080/21505594.2015.1014270 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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