Comparison of the Effects of Zolpidem and Flunitrazepam on Sleep Structure and Daytime Cognitive Functions - A Study of Untreated Unsomniacs
| Autor: | B de la Giclais, K Dujardin, Jean-Daniel Guieu, C Leconte-Lambert, P Leconte, P Borderies |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Zolpidem Pyridines medicine.drug_class Polysomnography Flunitrazepam Bedtime Hypnotic Cognition Sleep Initiation and Maintenance Disorders medicine Insomnia Humans Hypnotics and Sedatives Pharmacology (medical) GABA Modulators Slow-wave sleep Sleep disorder medicine.diagnostic_test musculoskeletal neural and ocular physiology General Medicine Middle Aged medicine.disease Psychiatry and Mental health Anesthesia medicine.symptom Sleep Psychology psychological phenomena and processes medicine.drug |
| Zdroj: | Pharmacopsychiatry. 31:14-18 |
| ISSN: | 1439-0795 0176-3679 |
| DOI: | 10.1055/s-2007-979289 |
| Popis: | The effects of zolpidem 10 mg, flunitrazepam 1 mg, and placebo, administrated at bedtime, were studied in 12 healthy male insomniac patients. The assessments included polygraphic sleep recordings during the night and a battery of cognitive tests (sign crossing test, dichotic listening test, digit span test, visual recognition test and free recall test during four times during the following day. Compared with placebo, both active drugs improved sleep parameters. However, with zolpidem, the results were not statistically different from placebo. Zolpidem dit not alter sleep architecture in contrast to flunitrazepam, which significantly increased stage 2 and decreased slow wave sleep and REM sleep. No significant interaction was found between time of day for the evaluation of cognitive function. Flunitrazepam significantly impaired attention and memory compared with zolpidem and placebo, while zolpidem did not differ from placebo. These results indicate that zolpidem 10 mg preserved sleep structure and daytime cognitive functions in contrast to flunitrazepam. |
| Databáze: | OpenAIRE |
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