Expression of the interleukin 17 in cortical tubers of the tuberous sclerosis complex
| Autor: | Jiao-Jiang He, Song Li, Hui Yang, Kefu Wu, Chun-Qing Zhang, Hai-Feng Shu, Mei-Hua Yang, Shi-Yong Liu, Qing Yin |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Cortical tubers Pathology medicine.medical_specialty Inflammatory cytokine Immunology Clinical Neurology Biology Tuberous sclerosis Tuberous Sclerosis Interleukin 17 medicine Humans Immunology and Allergy Child Cerebral Cortex Receptors Interleukin-17 Epilepsy Innate immune system Microglia Interleukin-17 fungi Infant food and beverages Acquired immune system medicine.disease Tuberous sclerosis protein medicine.anatomical_structure Neurology Tuberous sclerosis complex Child Preschool Female Neurology (clinical) Immunostaining |
| Zdroj: | Journal of Neuroimmunology. 262:85-91 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2013.05.007 |
| Popis: | The role of interleukin 17 (IL-17) to epilepsy-associated cortical tubers of tuberous sclerosis complex (TSC) is unknown. We investigated the expression patterns of the IL-17 and IL-17 receptor (IL-17R) in cortical tubers of TSC compared with normal control cortex (CTX). We found that IL-17 and IL-17R were clearly upregulated in cortical tubers at the protein levels. Immunostaining indicated that IL-17 was specifically distributed in the innate immunity cells (DNs, GCs, astrocytes, and microglia) and adaptive immunity cells (T-lymphocytes) as well as the endothelial cells of blood vessels. The overexpression and distribution patterns of IL-17 may be involved in the epileptogenicity of cortical tubers in TSC. |
| Databáze: | OpenAIRE |
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