On the relationship between glucose absorption and glucose-stimulated secretion of GLP-1, neurotensin, and PYY from different intestinal segments in the rat
Autor: | Nicolai J. Wewer Albrechtsen, Rune E. Kuhre, C. Christiansen, Monika Yosifova Saltiel, Jens J. Holst |
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Jazyk: | angličtina |
Předmět: |
0301 basic medicine
Male medicine.medical_specialty Physiology Colon media_common.quotation_subject neurotensin Peptide hormone lcsh:Physiology Signalling Pathways 03 medical and health sciences chemistry.chemical_compound Glucagon-Like Peptide 1 Physiology (medical) Internal medicine medicine peptide YY Animals Secretion Rats Wistar Digestive Absorption and Secretion media_common Original Research biology lcsh:QP1-981 digestive oral and skin physiology Appetite Glucagon-like peptide-1 Small intestine Rats Glucagon‐like peptide‐1 030104 developmental biology Endocrinology medicine.anatomical_structure Glucose glucose absorption chemistry Intestinal Absorption Peptide YY biology.protein GLUT2 Gastrointestinal Motility isolated perfused intestine hormones hormone substitutes and hormone antagonists Neurotensin |
Zdroj: | Kuhre, R E, Christiansen, C B, Saltiel, M Y, Albrechtsen, N J W & Holst, J J 2017, ' On the relationship between glucose absorption and glucose-stimulated secretion of GLP-1, neurotensin, and PYY from different intestinal segments in the rat ', Physiological Reports, vol. 5, no. 23, e13507 . https://doi.org/10.14814/phy2.13507 Physiological Reports University of Copenhagen Physiological Reports, Vol 5, Iss 23, Pp n/a-n/a (2017) |
ISSN: | 2051-817X |
DOI: | 10.14814/phy2.13507 |
Popis: | Ingested glucose powerfully stimulates the secretion of appetite‐ and metabolism‐regulating peptide hormones from the gut – including glucagon‐like peptide‐1 (GLP‐1), neurotensin (NT), and polypeptide YY (PYY). However, the regional origin of these secretions after glucose stimulation is not well characterized, and it remains uncertain how their secretion is related to glucose absorption. We isolated and perfused either the upper (USI) or the lower (LSI) small intestine or the colon from rats and investigated concomitant glucose absorption and secretory profiles of GLP‐1, NT, and PYY. In the USI and LSI luminal glucose (20%, w/v) increased GLP‐1 and NT secretion five to eightfold compared to basal secretion. Compared to the USI, basal and stimulated GLP‐1 secretion from the colon was 8–10 times lower and no NT secretion was detected. Luminal glucose stimulated secretion of PYY four to fivefold from the LSI and from the USI and colon, but the responses in the USI and colon were 5‐ to 15‐fold lower than in the LSI. Glucose was absorbed to a comparable extent in the USI and LSI by mechanisms that partly depended on both SGLT1 and GLUT2 activity, whereas the absorption in the colon was 80–90% lower. The absorption rates were, however, similar when adjusted for segmental length. Glucose absorption rates and NT, PYY and in particular GLP‐1 secretion were strongly correlated (P |
Databáze: | OpenAIRE |
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