On the relationship between glucose absorption and glucose-stimulated secretion of GLP-1, neurotensin, and PYY from different intestinal segments in the rat

Autor: Nicolai J. Wewer Albrechtsen, Rune E. Kuhre, C. Christiansen, Monika Yosifova Saltiel, Jens J. Holst
Jazyk: angličtina
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Physiology
Colon
media_common.quotation_subject
neurotensin
Peptide hormone
lcsh:Physiology
Signalling Pathways
03 medical and health sciences
chemistry.chemical_compound
Glucagon-Like Peptide 1
Physiology (medical)
Internal medicine
medicine
peptide YY
Animals
Secretion
Rats
Wistar

Digestive Absorption and Secretion
media_common
Original Research
biology
lcsh:QP1-981
digestive
oral
and skin physiology

Appetite
Glucagon-like peptide-1
Small intestine
Rats
Glucagon‐like peptide‐1
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Glucose
glucose absorption
chemistry
Intestinal Absorption
Peptide YY
biology.protein
GLUT2
Gastrointestinal Motility
isolated perfused intestine
hormones
hormone substitutes
and hormone antagonists

Neurotensin
Zdroj: Kuhre, R E, Christiansen, C B, Saltiel, M Y, Albrechtsen, N J W & Holst, J J 2017, ' On the relationship between glucose absorption and glucose-stimulated secretion of GLP-1, neurotensin, and PYY from different intestinal segments in the rat ', Physiological Reports, vol. 5, no. 23, e13507 . https://doi.org/10.14814/phy2.13507
Physiological Reports
University of Copenhagen
Physiological Reports, Vol 5, Iss 23, Pp n/a-n/a (2017)
ISSN: 2051-817X
DOI: 10.14814/phy2.13507
Popis: Ingested glucose powerfully stimulates the secretion of appetite‐ and metabolism‐regulating peptide hormones from the gut – including glucagon‐like peptide‐1 (GLP‐1), neurotensin (NT), and polypeptide YY (PYY). However, the regional origin of these secretions after glucose stimulation is not well characterized, and it remains uncertain how their secretion is related to glucose absorption. We isolated and perfused either the upper (USI) or the lower (LSI) small intestine or the colon from rats and investigated concomitant glucose absorption and secretory profiles of GLP‐1, NT, and PYY. In the USI and LSI luminal glucose (20%, w/v) increased GLP‐1 and NT secretion five to eightfold compared to basal secretion. Compared to the USI, basal and stimulated GLP‐1 secretion from the colon was 8–10 times lower and no NT secretion was detected. Luminal glucose stimulated secretion of PYY four to fivefold from the LSI and from the USI and colon, but the responses in the USI and colon were 5‐ to 15‐fold lower than in the LSI. Glucose was absorbed to a comparable extent in the USI and LSI by mechanisms that partly depended on both SGLT1 and GLUT2 activity, whereas the absorption in the colon was 80–90% lower. The absorption rates were, however, similar when adjusted for segmental length. Glucose absorption rates and NT, PYY and in particular GLP‐1 secretion were strongly correlated (P
Databáze: OpenAIRE
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