Insula Sensitivity to Unfairness in Alcohol Use Disorder
| Autor: | Nancy Diazgranados, Claire L. Mann, Michael Kerich, Markus Heilig, Carlos R. Cortes, David T. George, Erica N. Grodin, Melanie L. Schwandt, Reza Momenan, Xi Zhu, Karan Mathur |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Decision Making Emotions Original Manuscript Alcohol use disorder Audiology behavioral disciplines and activities 050105 experimental psychology Random Allocation 03 medical and health sciences 0302 clinical medicine mental disorders Reaction Time Social decision making medicine Humans 0501 psychology and cognitive sciences Rejection (Psychology) Social Behavior Cerebral Cortex Anterior insula Blood-oxygen-level dependent medicine.diagnostic_test Ultimatum game 05 social sciences General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging humanities Alcoholism Female Psychology Functional magnetic resonance imaging Insula psychological phenomena and processes Photic Stimulation 030217 neurology & neurosurgery |
| Zdroj: | Alcohol and Alcoholism. 53:201-208 |
| ISSN: | 1464-3502 0735-0414 |
| Popis: | Aims Social decision making has recently been evaluated in alcohol use disorder (AUD) using the ultimatum game (UG) task, suggesting a possible deficit in aversive emotion regulation elicited by the unfairness during this task. Despite the relevance to relapse of this possible faulty regulation, the brain correlates of the UG in AUD are unknown. Methods In total, 23 AUD and 27 healthy controls (HC) played three consecutive fMRI runs of the UG, while behavioral and brain responses were recorded. Results Overall, acceptance rate of unfair offers did not differ between groups, but there was a difference in the rate of behavioral change across runs. We found significant anterior insula (aINS) activation in both groups for both fair and unfair conditions, but only HC showed a trend towards increased activation during unfair vs. fair offers. There were not overall whole-brain between-group significant differences. We found a trend of signal attenuation, instead of an increase, in the aINS for AUD when compared to HC during the third run, which is consistent with our recent findings of selective insula atrophy in AUD. Conclusion We found differential group temporal dynamics of behavioral response in the UG. The HC group had a low acceptance rate for unfair offers in the first two runs that increased markedly for the third run; whereas the AUD group was consistent in their rejection of unfair offers across the three runs. We found a strong significant decrease in neural response across runs for both groups. Short summary This fMRI study of UG in alcohol use disorder found behavioral group differences in acceptance rate across runs, which together with significant BOLD-signal decrease across runs in UG-related regions in both groups, highlights the impairment of strategy in AUD and the effect of repetitive exposure to unfairness in this task. |
| Databáze: | OpenAIRE |
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