Prognostic value of urinary pyridinium crosslinks and their derivatives in multiple myeloma
| Autor: | Khalil Kargar Samani, Michel Blanc, Claire Mathiot, Isabelle Azais, Thierry Facon, Michel Brazier, Saïd Kamel, Jacques Jamart, Jérôme Jaubert, Xavier Leleu |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Deoxypyridinoline Pathology Bone disease Urinary system Pyridinium Compounds Gastroenterology Collagen Type I Bone resorption Bone remodeling chemistry.chemical_compound Predictive Value of Tests Internal medicine Humans Medicine Amino Acids Bone Resorption Multiple myeloma Aged Retrospective Studies Univariate analysis Pyridinoline business.industry Hematology General Medicine Prognosis medicine.disease Survival Analysis chemistry Female Collagen Multiple Myeloma Peptides business Biomarkers |
| Zdroj: | Annals of Hematology. 84:19-24 |
| ISSN: | 1432-0584 0939-5555 |
| DOI: | 10.1007/s00277-004-0937-9 |
| Popis: | Bone disease is a common feature of multiple myeloma (MM). The goal of this study was to assess the prognostic significance of urinary markers of bone metabolism in MM. Urinary levels of total pyridinoline (T-Pyd), deoxypyridinoline (T-Dpd), crosslinked N-telopeptide (Ntx), C-telopeptide (Ctx) of type I collagen and immunologic free deoxypyridinoline (f-Dpd) were assessed in 82 consecutive, previously untreated MM patients (aged 65–75 years) diagnosed between June 1995 and December 1998. A correlation between disease stage according to the Durie-Salmon classification and T-Pyd (p=0.034) and T-Dpd (p=0.007) was observed, while T-Pyd (p=0.015) and to a lesser extent f-Dpd (p=0.081) were correlated to bone involvement measured by plain X-ray. None were correlated to M-component or magnetic resonance imaging (MRI). In univariate analysis high T-Pyd (p=0.007), T-Dpd (p=0.027), f-Dpd (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink