Genetic and flow cytometry analysis of seronegative celiac disease: a cohort study
| Autor: | Enrique Rodríguez de Santiago, Laura Crespo Pérez, Garbiñe Roy Ariño, Ana De Andrés Martín, Raquel Ríos León, Carlota García Hoz Jiménez, Agustín Albillos, Eugenia Sánchez Rodríguez, Ana Saiz González, Francisco León Prieto |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Duodenum Tissue transglutaminase Biopsy Disease Gastroenterology Autoimmune thyroiditis Loss of heterozygosity Lesion Diet Gluten-Free Young Adult 03 medical and health sciences 0302 clinical medicine GTP-Binding Proteins HLA-DQ Antigens Internal medicine medicine Humans Protein Glutamine gamma Glutamyltransferase 2 Lymphocytes Duodenal Diseases Intestinal Mucosa Aged Autoantibodies Retrospective Studies Aged 80 and over Transglutaminases biology business.industry Retrospective cohort study Middle Aged Flow Cytometry medicine.disease Immunoglobulin A Celiac Disease Logistic Models 030220 oncology & carcinogenesis biology.protein Female 030211 gastroenterology & hepatology Atrophy medicine.symptom Antibody business Cohort study |
| Zdroj: | Scandinavian Journal of Gastroenterology. 54:563-570 |
| ISSN: | 1502-7708 0036-5521 |
| Popis: | Background: Seronegative celiac disease (CD) poses a diagnostic challenge.Aims: Characterize and identify differences between seronegative and seropositive CD.Patients and methods: Retrospective cohort study examining adult patients diagnosed with CD (1980–2017). Clinical, analytical, histological, genetic and immunophenotypic data were compiled. Seronegative CD was defined as a anti-tissue transglutaminase type 2 IgA and endomysial antibodies (EMA) negative and HLA-DQ2 and/or DQ8 positive, showing clinical signs of CD plus an abnormal duodenal biopsy, and responding to a gluten-free diet (GFD). Factors associated with seronegative CD were identified through binomial logistic regression.Results: Of 315 CD patients, 289 were seropositive (91.7%) and 26 seronegative (8.3%). Among the seronegative patients, higher prevalence was observed for autoimmune thyroiditis (26.9% vs. 9.7%, p = .016), HLA-DQ8 heterozygosity (23.1% vs. 2.5%, p ˂ .001) and Marsh I lesion (34.6% vs. 3.7%, p ˂ .001). The two group... |
| Databáze: | OpenAIRE |
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