Quorum Sensing in Candida albicans
| Autor: | Erin Burger, Timothy Niessen, Jacob M. Hornby, Patrick H. Dussault, Roman V. Shchepin, Kenneth W. Nickerson |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
biology Stereochemistry Clinical Biochemistry Germ tube General Medicine Farnesol biology.organism_classification Biochemistry Corpus albicans Quorum sensing chemistry.chemical_compound chemistry Drug Discovery Extracellular Molecular Medicine lipids (amino acids peptides and proteins) Mode of action Candida albicans Molecular Biology Cis–trans isomerism |
| Zdroj: | Chemistry & Biology. 10(8):743-750 |
| ISSN: | 1074-5521 |
| DOI: | 10.1016/s1074-5521(03)00158-3 |
| Popis: | The dimorphic fungus Candida albicans produces extracellular farnesol (3,7,11-trimethyl-2,6,10-dodecatriene-1-ol) which acts as a quorum-sensing molecule (QSM) to suppress filamentation. Of four possible geometric isomers of farnesol, only the E,E isomer possesses QSM activity. We tested 40 natural and synthetic analogs of farnesol for their activity in an N-acetylglucosamine-induced differentiation assay for germ tube formation (GTF). Modified structural features include the head group, chain length, presence or absence of the three double bonds, substitution of a backbone carbon by S, O, N, and Se heteroatoms, presence or absence of a 3-methyl branch, and the bulkiness of the hydrophobic tail. Of the 40 compounds, 22 showed QSM activity by their ability to reduce GTF by 50%. However, even the most active of the analogs tested had only 7.3% of the activity of E,E-farnesol. Structure-activity relationships were examined in terms of the likely presence in C. albicans of a farnesol binding receptor protein. |
| Databáze: | OpenAIRE |
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