CART Peptides Regulate Psychostimulants and May be Endogenous Antidepressants
| Autor: | Kuhar Mj, McNamara Im, Job Mo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Cart
Endogeny Nucleus accumbens Pharmacology Article Arousal immune system diseases arousal parasitic diseases mental disorders Medicine Pharmacology (medical) forced swim test antidepressant business.industry virus diseases General Medicine CART peptide anxiety Psychiatry and Mental health Neurology nervous system depression drug abuse Antidepressant Anxiety Neurology (clinical) Animal studies medicine.symptom business Neuroscience Behavioural despair test |
| Zdroj: | Current Neuropharmacology |
| ISSN: | 1875-6190 1570-159X |
| Popis: | CART peptides are endogenous neurotransmitters that are involved in a variety of physiologic functions. Injection of CART 55-102 into the nucleus accumbens produces no effect, but when co-administered with cocaine, it reduces the locomotor and rewarding properties of cocaine. In a human study, subjects carrying a missense mutation of the CART gene exhibited increased anxiety and depression. Also, several animal studies support the idea that CART is involved in anxiety and depression, and they also suggest several possible mechanisms by which this may occur. Thus, there is interesting evidence that CART peptides play a role in anxiety and depression, and that CART peptides may be endogenous antidepressants. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|