Spatio-temporal specialization of GABAergic septo-hippocampal neurons for rhythmic network activity

Autor: Thomas Klausberger, Linda Katona, Michael G Crump, Peter Somogyi, Gunes Unal, Tim J. Viney, Tímea Éltes
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Histology
Interneuron
Vesicular Acetylcholine Transport Proteins
Action Potentials
Hippocampus
Hippocampal formation
Biology
Receptors
Metabotropic Glutamate
Basal forebrain
Rats
Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
Rhythm
Postsynaptic potential
Neural Pathways
Image Processing
Computer-Assisted
medicine
Animals
GABAergic Neurons
Theta Rhythm
Septo-hippocampal
Microscopy
Confocal
General Neuroscience
Membrane Proteins
Theta
Temporal Lobe
Network activity
Rats
Sharp wave-ripple
030104 developmental biology
medicine.anatomical_structure
nervous system
GABAergic
Vesicular Glutamate Transport Protein 2
Original Article
Septum of Brain
Nerve Net
Anatomy
Carrier Proteins
Neuroscience
030217 neurology & neurosurgery
Vasoactive Intestinal Peptide
Zdroj: Brain Structure & Function
ISSN: 1863-2661
1863-2653
Popis: Medial septal GABAergic neurons of the basal forebrain innervate the hippocampus and related cortical areas, contributing to the coordination of network activity, such as theta oscillations and sharp wave-ripple events, via a preferential innervation of GABAergic interneurons. Individual medial septal neurons display diverse activity patterns, which may be related to their termination in different cortical areas and/or to the different types of innervated interneurons. To test these hypotheses, we extracellularly recorded and juxtacellularly labeled single medial septal neurons in anesthetized rats in vivo during hippocampal theta and ripple oscillations, traced their axons to distant cortical target areas, and analyzed their postsynaptic interneurons. Medial septal GABAergic neurons exhibiting different hippocampal theta phase preferences and/or sharp wave-ripple related activity terminated in restricted hippocampal regions, and selectively targeted a limited number of interneuron types, as established on the basis of molecular markers. We demonstrate the preferential innervation of bistratified cells in CA1 and of basket cells in CA3 by individual axons. One group of septal neurons was suppressed during sharp wave-ripples, maintained their firing rate across theta and non-theta network states and mainly fired along the descending phase of CA1 theta oscillations. In contrast, neurons that were active during sharp wave-ripples increased their firing significantly during "theta" compared to "non-theta" states, with most firing during the ascending phase of theta oscillations. These results demonstrate that specialized septal GABAergic neurons contribute to the coordination of network activity through parallel, target area- and cell type-selective projections to the hippocampus.
Databáze: OpenAIRE
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