Correlation of redox potentials and inhibitory effects on Epstein-Barr virus activation of 2-azaanthraquinones

Autor:	Junko Koyama, Izumi Morita, Norihiro Kobayashi, Toshiyuki Osakai, Hiroki Hotta, Junko Takayasu, Hoyoku Nishino, Harukuni Tokuda
Rok vydání:	2004
Předmět:	Electrophysiology Structure-Activity Relationship Cancer Research Oncology Anthraquinones Hydrogen-Ion Concentration Antigens Viral Oxidation-Reduction
Zdroj:	Cancer Letters. 212:1-6
ISSN:	0304-3835
DOI:	10.1016/j.canlet.2004.03.005
Popis:	As a continuation of our studies using natural and synthetic products as cancer chemopreventive agents, we examined the standard redox potentials of some 2-azaanthraquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the 2-azaanthraquinones on Epstein-Barr virus early antigen (EBV-EA) activation. It has been further shown that the correlation can be enhanced by introducing an electronic properties, i.e. the atomic charges at the C5 and O12 atoms in the quinone skeleton ring and the HOMO energy as additional parameters.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d6fb34e37a71fe4de4b769c86d7b13 https://doi.org/10.1016/j.canlet.2004.03.005 Zobrazit plný text záznamu Full Text from ScienceDirect