Hypoglycemic activity of oral hypoglycemics with increased hydrophilicity

Autor:	Sobhl A. Said, Hasan I. Al-Shora
Rok vydání:	1981
Předmět:	Blood Glucose Male Chemistry Pharmaceutical Science Administration Oral Water Capsules Absorption (skin) Pharmacology Methylcellulose Rats Tolbutamide Acetohexamide Solubility medicine Animals Hypoglycemic Agents Dissolution testing Powders Dissolution medicine.drug
Zdroj:	Journal of pharmaceutical sciences. 70(1)
ISSN:	0022-3549
Popis:	The effect of increasing the hydrophilicity of acetohexamide and tolbutamide with hydroxypropyl methylcellulose and methylcellulose on drug dissolution and hypoglycemic activity in rats was examined. The dissolution rate of both drugs was increased according to the type and concentration of the polymer. The oral absorption of both drugs was improved, as indicated by potentiation of the reduction in blood glucose in rats. The efficiency of the polymer in increasing the dissolution rates of the drugs correlated with the hydrophilicity of the polymer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d52c9540f417c1a22a1d11e17889dc https://pubmed.ncbi.nlm.nih.gov/7229933 Zobrazit plný text záznamu Plný text