| Popis: |
Allergic rhinitis is an immunological disorder and an inflammatory response of nasal mucosal membranes. Allergic rhinitis, a state of hypersensitivity, occurs when the bodyoverreacts to a substance such as pollens or dust. A novel, safe polyherbal formulation (Aller-7=NR-A2) has been developed for the treatment of allergic rhinitis using a unique combination of extracts from seven medicinal plants including Phyllanthus emblica, Terminalia chebula, Terminalia bellerica, Albizia lebbeck, Piper nigrum, Zingiber officinale, and Piper longum. A number of safety and toxicity studies including acute oral, dermal, primary dermal irritation, eye irritation, subacute, subchronic, mutagenicity, reproductive toxicity, and teratogenicity, were evaluated, which demonstrated the broad spectrum safety of Aller-7. In conjunction, a number of mechanistic studies including mast cell stabilization, hyaluronidase, lipoxygenase, and trypsin inhibitory activities, antispasmodic, antihistaminic, anti-inflammatory, and antioxidant activities, were conducted to demonstrate the efficacy of Aller-7. Finally, clinical studies were conducted to demonstrate the clinical efficacy of Aller-7. No significant adverse effects were observed. Taken together, these studies demonstrate the safety and efficacy of Aller-7 in ameliorating the symptoms of allergic rhinitis. |
