Serotype Diversity and Antimicrobial Resistance of Streptococcus pneumoniae
| Autor: | Katosova Lk, Aliab'eva Nm, Lazareva Av, Maianskiĭ Na |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
medicine.drug_class
Antibiotics Microbial Sensitivity Tests Biology Serogroup medicine.disease_cause Pneumococcal Infections Microbiology Antibiotic resistance Anti-Infective Agents Streptococcus pneumoniae medicine Humans Serotyping Vaccines Conjugate Immunization Programs Drug Resistance Microbial General Medicine medicine.disease Vaccination Pneumonia Pneumococcal infections Bacteremia Immunology Meningitis |
| Zdroj: | Annals of the Russian academy of medical sciences. 69:38-45 |
| ISSN: | 0869-6047 |
| Popis: | The pneumococcus (Streptococcus pneumoniae) is a common bacterial pathogen responsible for various infections, especially in children below 5 years of age. The severity of pneumococcal infections varies from self-limiting mucosal infections, including acute otitis media, sinusitis, and noninvasive pneumonia, to life-threatening invasive disease like bacteremia and meningitis. A high incidence of pneumococcal infections is combined with a constantly growing antibiotic resistance of this pathogen. The growing resistance is thought to be associated with misuse of antibiotics and emerging of resistant clones that may spread throughout the entire population. Pneumococcal polysaccharide conjugate vaccines (PCV) contain an assortment of pneumococcal capsular polysaccharides (from 7 to 13) that produce serotype-specific protective antibodies. Since early 2000's, the introduction of PCV into national immunization programs has been shown to substantially decrease the incidence of invasive pneumococcal disease and pneumococcal carriage associated with vaccine-type pneumococci in many countries. In 2014, PCV vaccination was included in the Russian national calendar of prophylactic vaccination. The present article reviews the current literature on serotype prevalence, antibiotic susceptibility, and PCV effect on the evolution of pneumococcus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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