Antifungal activity and toxicity studies of flavanones isolated from Tessaria dodoneifolia aerial parts

Autor: Diego A. Sampietro, Jose Rodolfo Soberon, Melina Araceli Sgariglia, Franco A. Aguilar, José A. Carabajal Torrez, Edgardo J. I. Pero, Julia Fernández de Luco, Guillermo R. Labadie
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Naringenin
Toxicity assays
Flavonoid
TESSARIA DODONEIFOLIA
Bacillus subtilis
Toxicology
Tessaria
chemistry.chemical_compound
0302 clinical medicine
Candida albicans
Antifungal activity
lcsh:Social sciences (General)
Spectroscopy
chemistry.chemical_classification
Tessaria dodoneifolia
Plant biology
Chromatography
Multidisciplinary
Pinocembrin
SPECTROSCOPY
biology
SECONDARY METABOLITE
purl.org/becyt/ford/4.4 [https]
lcsh:H1-99
medicine.drug
Research Article
TOXICOLOGY
Mycology
Secondary metabolite
Microbiology
03 medical and health sciences
MYCOLOGY
Bioactive plant product
medicine
TOXICITY ASSAYS
lcsh:Science (General)
biology.organism_classification
SYNERGISTIC EFFECT
030104 developmental biology
chemistry
Synergistic effect
PLANT BIOLOGY
030217 neurology & neurosurgery
Fluconazole
purl.org/becyt/ford/4 [https]
lcsh:Q1-390
Zdroj: Heliyon, Vol 6, Iss 10, Pp e05174-(2020)
Heliyon
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
ISSN: 2405-8440
Popis: Tessaria dodoneifolia [Asteraceae] is traditionally employed in Northwestern Argentina for fungal infections treatment. We report the antifungal activity guided isolation and identification of substances from aerial parts of this species, both individually and in combination with fluconazole (FLU), against Candida albicans strains. Two antifungal flavanones were identified as naringenin (NAR) and pinocembrin (PIN). These compounds could individually inhibit the growth of C. albicans strains. Combinations of NAR and PIN with FLU were synergistic against the FLU resistant and sensitive C. albicans strains. Genotoxic and cytotoxic evaluations were also performed. NAR, PIN and their combinations with FLU did not have a genotoxic effect on Bacillus subtilis rec strains. Finally, these compounds did not show cytotoxicity at concentrations below 80 μg/mL.
Plant biology; Toxicology; Bioactive plant product; Mycology; Secondary metabolite; Flavonoid; Chromatography; Spectroscopy; Tessaria dodoneifolia; Antifungal activity; Candida albicans; Synergistic effect; Toxicity assays.
Databáze: OpenAIRE
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