Are all type I human interferons equivalent?

Autor:	N. B. Finter, Graham R. Foster
Rok vydání:	1998
Předmět:	Interferon receptor Hepatology Interferon-alpha Interferon-beta Biology Antibodies Infectious Diseases Interferon Virus Diseases Virology Immunology Interferon Type I medicine Animals Humans Signal transduction Signalling pathways medicine.drug Signal Transduction
Zdroj:	Journal of viral hepatitis. 5(3)
ISSN:	1352-0504
Popis:	The Type I interferons are a family of closely related cytokines that have antiviral and immunostimulatory properties. There has been prolonged debate regarding the different interferon-alpha subtypes: with some authorities suggest that the different interferons have essentially similar properties but others argue that there are significant differences between them. Recent work has shown that the various interferon-alpha subtypes can interact with the interferon receptor components in different ways and can activate a number of different signalling pathways. Recent studies on the immunomodulatory properties of the Type I interferons indicate that there are profound differences between the subtypes. The clinical significance of all these differences remains to be determined.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cf5e5e78cb2a58b4ed25fbaa0f3f37 https://pubmed.ncbi.nlm.nih.gov/9658366 Zobrazit plný text záznamu Plný text ve formátu PDF