Relationship between Toxicokinetics of Carbaryl and Effect on Acetylcholinesterase Activity in Pomacea patula Snail
| Autor: | Gilberto Castañeda Hernández, Ma Concepción Gutiérrez Ruiz, Francisco Javier Flores Murrieta, Laura Martínez-Tabche, Beatriz Ramirez Mora, Eugenia Sánchez-Hidalgo |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Insecticides
Carbamate biology Health Toxicology and Mutagenesis medicine.medical_treatment Snails Public Health Environmental and Occupational Health Bioconcentration General Medicine Snail Pesticide Carbaryl Pollution Acetylcholinesterase Toxicology chemistry.chemical_compound Animal science chemistry biology.animal Toxicity medicine Animals Toxicokinetics Cholinesterase Inhibitors |
| Zdroj: | Ecotoxicology and Environmental Safety. 46:234-239 |
| ISSN: | 0147-6513 |
| DOI: | 10.1006/eesa.1999.1911 |
| Popis: | The 96-h LC(50) value of carbaryl was 14.6 microg/mL for the snail Pomacea patula. Organisms were exposed for 72 h to a low sublethal concentration (0.1 of LC(50)) using a semistatic contamination system; bioconcentration and elimination experiments were performed evaluating simultaneously acetylcholinesterase (ACHase) activity. The inhibition of the digestive gland ACHase reached 76% when the carbaryl concentration in tissue was 3.2 microg/g. The increased enzyme inhibition was observed concomitantly with the bioconcentration of carbaryl until 7 h. ACHase inhibition was linearly dependent on the uptake and bioconcentration of carbaryl (r(2)=0.87). The transfer of snails to carbaryl-free water after 72 h of exposure was followed by rapid monophasic elimination with a half-life of 1.0 h. However, ACHase activity levels never returned to control values. These results revealed that the bioconcentration might play a critical role in contributing to the toxicity of carbaryl. |
| Databáze: | OpenAIRE |
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