Using Supercritical Fluid Technology as a Green Alternative During the Preparation of Drug Delivery Systems
| Autor: | Paroma Chakravarty, Amin Famili, Karthik Nagapudi, Mohammad Al-Sayah |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
liposomes
Materials science Pharmaceutical Science Nanoparticle Nanotechnology 02 engineering and technology Review foams 010402 general chemistry supercritical fluids 01 natural sciences drug delivery systems Solid lipid nanoparticle Dissolution Active ingredient microparticles aerogels 021001 nanoscience & nanotechnology Environmentally friendly Supercritical fluid 0104 chemical sciences membranes Drug delivery nanoparticles 0210 nano-technology Drug carrier |
| Zdroj: | Pharmaceutics |
| ISSN: | 1999-4923 |
| Popis: | Micro- and nano-carrier formulations have been developed as drug delivery systems for active pharmaceutical ingredients (APIs) that suffer from poor physico-chemical, pharmacokinetic, and pharmacodynamic properties. Encapsulating the APIs in such systems can help improve their stability by protecting them from harsh conditions such as light, oxygen, temperature, pH, enzymes, and others. Consequently, the API’s dissolution rate and bioavailability are tremendously improved. Conventional techniques used in the production of these drug carrier formulations have several drawbacks, including thermal and chemical stability of the APIs, excessive use of organic solvents, high residual solvent levels, difficult particle size control and distributions, drug loading-related challenges, and time and energy consumption. This review illustrates how supercritical fluid (SCF) technologies can be superior in controlling the morphology of API particles and in the production of drug carriers due to SCF’s non-toxic, inert, economical, and environmentally friendly properties. The SCF’s advantages, benefits, and various preparation methods are discussed. Drug carrier formulations discussed in this review include microparticles, nanoparticles, polymeric membranes, aerogels, microporous foams, solid lipid nanoparticles, and liposomes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |