The role of chalcones: helichrysetin, xanthohumol, and flavokawin-C in promoting neurite outgrowth in PC12 Adh cells
| Autor: | Wai-Kuan Yong, Chia-Wei Phan, Vikineswary Sabaratnam, Sri Nurestri Abd Malek |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Chalcone Neurite Neuronal Outgrowth Drug Evaluation Preclinical Plant Science Biology 01 natural sciences Biochemistry PC12 Cells Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound Chalcones Extracellular Neurites Animals Nerve Growth Factors Flavonoids Propiophenones Organic Chemistry Molecular biology 0104 chemical sciences Rats 010404 medicinal & biomolecular chemistry 030104 developmental biology Nerve growth factor chemistry Rat Pheochromocytoma Xanthohumol Helichrysetin |
| DOI: | 10.6084/m9.figshare.5039171 |
| Popis: | Chalcones are a group of compounds widely distributed in plant kingdom. The aim of this study was to assess the neurite outgrowth stimulatory activity of selected chalcones, namely helichrysetin, xanthohumol and flavokawin-C. Using adherent rat pheochromocytoma (PC12 Adh) cells, the chalcones were subjected to neurite outgrowth assay and the extracellular nerve growth factor (NGF) levels were determined. Xanthohumol (10 μg/mL) displayed the highest (p |
| Databáze: | OpenAIRE |
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