Ribociclib-Related Stevens–Johnson Syndrome: Oncologic Awareness, Case Report, and Literature Review
| Autor: | Santos Enrech, Enrique Revilla, Héctor Muñoz-González, Pablo Tolosa, Ramón Yarza, Olga González-Valle, Victoria López-Gómez, Eva Ciruelos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cycline-dependent kinase inhibitor Cancer Research medicine.medical_specialty Population Mucocutaneous zone Ribociclib Case Report Stevens-Johnson syndrome 03 medical and health sciences 0302 clinical medicine Breast cancer Medicine education education.field_of_study integumentary system business.industry Cancer Stevens johnson Toxic epidermal necrolysis Skin toxicity medicine.disease Dermatology Discontinuation stomatognathic diseases 030104 developmental biology Oncology 030220 oncology & carcinogenesis business |
| Zdroj: | Journal of Breast Cancer |
| ISSN: | 2092-9900 1738-6756 |
| Popis: | Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis belong to a severe dermatopathic spectrum that includes frequently fatal mucocutaneous manifestations consisting of whole epidermal necrosis and sloughing with bullous transformation, blistering, and further skin detachment. Notably, cancer patients are at higher risk of developing SJS than the general population as a consequence of both the nature of neoplastic disease and frequent exposure to anticancer drugs. Ribociclib is a newly approved cycline-dependent kinase inhibitor that has been recently associated with a single case of SJS. We hereby present a case of ribociclib-related SJS. Early detection of threatening skin lesions is crucial to permit the immediate discontinuation of ribociclib given the predictable and unacceptable risk level. In cases of established SJS, early aggressive support should be initiated, ribociclib should be abruptly discontinued, and specific treatment based on actual evidence should be started. |
| Databáze: | OpenAIRE |
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