Ugi 4-CR synthesis of gamma- and delta-lactams providing new access to diverse enzyme interactions
| Autor: | Alexander Dömling, Ting Zhao, George P. Liao, Eberhardt Herdtweck, André Boltjes |
|---|---|
| Přispěvatelé: | Drug Design, Medicinal Chemistry and Bioanalysis (MCB) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
SURROGATE
PROTEASE Stereochemistry Protein Data Bank (RCSB PDB) Pharmaceutical Science Bioinformatics Biochemistry Article DESIGN Drug Discovery Binding site Pharmacology chemistry.chemical_classification AMMONIA Chemistry Hydrogen bond Organic Chemistry Rupintrivir RUPINTRIVIR Enzyme Interaction ENTEROVIRUS-71 INFECTION Acceptor Amino acid PROMISING CANDIDATE Molecular Medicine INHIBITORS |
| Zdroj: | MedChemCommun, 5(7), 949-952. ROYAL SOC CHEMISTRY |
| ISSN: | 2040-2511 2040-2503 |
| Popis: | A three step synthesis of N-unsubstituted tetrazolo gamma- and delta-lactams involving a key Ugi-4CR is presented. The compounds, otherwise difficult to access, are conveniently synthesized in overall good yields by our route. PDB analysis of the N-unsubstituted gamma- and delta-lactam fragment reveals a strongly tri-directional hydrogen bond donor acceptor interaction with the amino acids of the binding sites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|