The MHC locus and genetic susceptibility to autoimmune and infectious diseases

Autor: Vasiliki Matzaraki, Alexandra Zhernakova, Cisca Wijmenga, Vinod Kumar
Rok vydání: 2017
Předmět:
0301 basic medicine
lcsh:QH426-470
Human Papilloma Virus
HL-A ANTIGENS
Genome-wide association study
Ankylose Spondylitis
Classic Human Leukocyte Antigen
Review
Human leukocyte antigen
Biology
IMMUNOGLOBULIN-LIKE RECEPTORS
Major histocompatibility complex
Communicable Diseases
Autoimmune Diseases
Major Histocompatibility Complex
03 medical and health sciences
AMINO-ACID POSITIONS
HLA Antigens
medicine
Genetic predisposition
Humans
Genetic Predisposition to Disease
GENOME-WIDE ASSOCIATION
SYSTEMIC-LUPUS-ERYTHEMATOSUS
lcsh:QH301-705.5
Genetic Association Studies
Autoimmune disease
Genetics
Genetic Variation
Epistasis
Genetic
medicine.disease
Human genetics
RHEUMATOID-ARTHRITIS
Human Leukocyte Antigen
3. Good health
lcsh:Genetics
030104 developmental biology
lcsh:Biology (General)
Immunology
biology.protein
CHRONIC HEPATITIS-B
C VIRUS-INFECTION
Imputation (genetics)
INFLAMMATORY-BOWEL-DISEASE
Genetic screen
Zdroj: Genome Biology
Genome Biology, Vol 18, Iss 1, Pp 1-21 (2017)
ISSN: 1474-760X
1465-6906
DOI: 10.1186/s13059-017-1207-1
Popis: In the past 50 years, variants in the major histocompatibility complex (MHC) locus, also known as the human leukocyte antigen (HLA), have been reported as major risk factors for complex diseases. Recent advances, including large genetic screens, imputation, and analyses of non-additive and epistatic effects, have contributed to a better understanding of the shared and specific roles of MHC variants in different diseases. We review these advances and discuss the relationships between MHC variants involved in autoimmune and infectious diseases. Further work in this area will help to distinguish between alternative hypotheses for the role of pathogens in autoimmune disease development. Electronic supplementary material The online version of this article (doi:10.1186/s13059-017-1207-1) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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