Union is strength: matrix elasticity and microenvironmental factors codetermine stem cell differentiation fate
| Autor: | Lisha Li, Yuanyuan Liu, Zhishen Chen, Yulin Li, Licheng Tian, Hongwei Lv, Man Lu, Tiankai Xu, Min Ren, Meiyu Sun, Yin Zhang |
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| Rok vydání: | 2014 |
| Předmět: |
Histology
Tissue Engineering business.industry Cellular differentiation Stem Cells Cell Differentiation Cell Biology Biology Proteomics Regenerative Medicine Lineage specification Regenerative medicine Pathology and Forensic Medicine Cell biology Biotechnology Extracellular Matrix Extracellular matrix Tissue engineering Animals Humans Cell Lineage Elasticity (economics) Stem cell business |
| Zdroj: | Cell and tissue research. 361(3) |
| ISSN: | 1432-0878 |
| Popis: | Stem cells are an attractive cellular source for regenerative medicine and tissue engineering applications due to their multipotency. Although the elasticity of the extracellular matrix (ECM) has been shown to have crucial impacts in directing stem cell differentiation, it is not the only contributing factor. Many researchers have recently attempted to design microenvironments that mimic the stem cell niche with combinations of ECM elasticity and other cues, such as ECM physical properties, soluble biochemical factors and cell–cell interactions, thereby driving cells towards their preferred lineages. Here, we briefly discuss the effect of matrix elasticity on stem cell lineage specification and then summarize recent advances in the study of the combined effects of ECM elasticity and other cues on the differentiation of stem cells, focusing on two aspects: biophysical and biochemical factors. In the future, biomedical scientists will continue investigating the union strength of matrix elasticity and microenvironmental cues for manipulating stem cell fates. |
| Databáze: | OpenAIRE |
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