A Simplified Local Control Model of Calcium-Induced Calcium Release in Cardiac Ventricular Myocytes
| Autor: | Raimond L. Winslow, Linmiao Xu, Robert Hinch, Joseph L. Greenstein, Antti J. Tanskanen |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Calcium Channels L-Type Biophysics chemistry.chemical_element Gating Biophysical Theory and Modeling 030204 cardiovascular system & hematology Calcium Membrane Potentials 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Myocyte Animals Humans Ventricular Function Computer Simulation Myocytes Cardiac Calcium Signaling 030304 developmental biology Calcium signaling Membrane potential 0303 health sciences Chemistry Endoplasmic reticulum Cell Membrane Models Cardiovascular Ryanodine Receptor Calcium Release Channel Myocardial Contraction Coupling (electronics) Endocrinology cardiovascular system Calcium-induced calcium release Ion Channel Gating |
| Zdroj: | Biophysical Journal. 87(6):3723-3736 |
| ISSN: | 0006-3495 |
| DOI: | 10.1529/biophysj.104.049973 |
| Popis: | Calcium (Ca2+)-induced Ca2+ release (CICR) in cardiac myocytes exhibits high gain and is graded. These properties result from local control of Ca2+ release. Existing local control models of Ca2+ release in which interactions between L-Type Ca2+ channels (LCCs) and ryanodine-sensitive Ca2+ release channels (RyRs) are simulated stochastically are able to reconstruct these properties, but only at high computational cost. Here we present a general analytical approach for deriving simplified models of local control of CICR, consisting of low-dimensional systems of coupled ordinary differential equations, from these more complex local control models in which LCC-RyR interactions are simulated stochastically. The resulting model, referred to as the coupled LCC-RyR gating model, successfully reproduces a range of experimental data, including L-Type Ca2+ current in response to voltage-clamp stimuli, inactivation of LCC current with and without Ca2+ release from the sarcoplasmic reticulum, voltage-dependence of excitation-contraction coupling gain, graded release, and the force-frequency relationship. The model does so with low computational cost. |
| Databáze: | OpenAIRE |
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