Clinically feasible diffusion MRI in muscle: Time dependence and initial findings in Duchenne muscular dystrophy
| Autor: | Thorsten Feiweier, Amy R. McDowell, Francesco Muntoni, Matthew Hall, Chris A. Clark |
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| Rok vydání: | 2021 |
| Předmět: |
Male
business.industry Duchenne muscular dystrophy Skeletal muscle medicine.disease Muscular Dystrophy Duchenne Diffusion Magnetic Resonance Imaging Nuclear magnetic resonance medicine.anatomical_structure Case-Control Studies Fractional anisotropy medicine Anisotropy Humans Radiology Nuclear Medicine and imaging Acquisition time Stimulated echo Muscular dystrophy Diffusion (business) Child Muscle Skeletal business Diffusion MRI |
| Zdroj: | Magnetic Resonance in Medicine. 86:3192-3200 |
| ISSN: | 1522-2594 0740-3194 |
| Popis: | Purpose To characterize the diffusion time-dependence in muscle in healthy adult volunteers, boys with Duchenne's muscular dystrophy (DMD), and age-matched controls in a clinically feasible acquisition time for pediatric applications. Methods Diffusion data were acquired using a pulsed gradient stimulated echo diffusion preparation at 5 different diffusion times (70, 130, 190, 250, and 330 ms), at 4 different b-values (0, 200, 400, 600, and 800 s/mm2 ) and 6 directions (orthogonal x, y, and z and diagonal xy, xz, and yz) and processed to obtain standard diffusion indices (mean diffusivity [MD] and fractional anisotropy [FA]) at each diffusion time. Results Time-dependent diffusion was seen in muscle in healthy adult volunteers, boys with DMD, and age-matched controls. Boys with DMD showed reduced MD and increased FA values in comparison to age matched controls across a range of diffusion times. A diffusion time of Δ = 190 ms had the largest effect size. Conclusions These results could be used to optimize diffusion imaging in this disease further and imply that these diffusion indices may become an important biomarker in monitoring progression in DMD in the future. |
| Databáze: | OpenAIRE |
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