Prognostic Value of Apolipoprotein E Epsilon4 Allele in Patients with Traumatic Brain Injury: A Meta-Analysis and Meta-Regression
| Autor: | Xuhui Wang, Min-Hui Xu, An-Qiang Zhang, Guangjian Shen, Shi Zeng, Jian-Xin Jiang, Lun-Shan Xu |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Genotype Traumatic brain injury Apolipoprotein E4 Subgroup analysis Cochrane Library Bioinformatics Young Adult Predictive Value of Tests Internal medicine mental disorders medicine Humans Child Alleles Genetics (clinical) Aged Aged 80 and over business.industry Infant General Medicine Odds ratio Middle Aged Prognosis medicine.disease Confidence interval nervous system diseases Brain Injuries Child Preschool Meta-analysis Predictive value of tests Regression Analysis Female lipids (amino acids peptides and proteins) business Biomarkers Cohort study |
| Zdroj: | Genetic Testing and Molecular Biomarkers. 18:202-210 |
| ISSN: | 1945-0257 1945-0265 |
| DOI: | 10.1089/gtmb.2013.0421 |
| Popis: | Current scientific evidence suggests that the apolipoprotein E epsilon4 (APOE4) allele may be associated with a good prognosis for patients with traumatic brain injury (TBI); however, many existing studies have yielded inconclusive results. This meta-analysis aims to obtain a more precise estimation of the association between APOE4 allele and prognosis of TBI patients.A literature search of PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, CNKI and CBM databases was conducted for articles published before July 1st, 2013. Crude odds ratios (OR) with 95% confidence intervals (CI) were calculated.Thirteen cohort studies were included with a total of 662 TBI patients with APOE4 (+) and 1614 TBI patients with APOE4 (-). The meta-analysis results revealed that the APOE4 allele was associated with a poor prognosis in TBI patients (OR=0.68, 95% CI: 0.48-0.96, p=0.027). Subgroup analysis by ethnicity indicated that TBI patients with APOE4 (+) had a worse prognosis than those with APOE4 (-) in Asian populations (OR=0.46, 95% CI: 0.21-0.99, p=0.046), but not in Caucasian populations (OR=0.75, 95% CI: 0.53-1.08, p=0.120). A further subgroup analysis by TBI grade showed that the APOE4 allele was associated with poor prognosis in severe TBI patients (OR=0.43, 95% CI: 0.21-0.87, p=0.020). However, there was no evidence for any association between the APOE4 allele and poor prognosis in patients with other grades of TBI (all p0.05).The current meta-analysis indicates that the APOE4 allele may be associated with a poor prognosis in severe TBI patients and in Asian populations. The APOE4 allele may be used as a biomarker in predicting the prognosis of TBI patients. |
| Databáze: | OpenAIRE |
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