Osteoprotegerin and RANKL in the pathogenesis of rheumatoid arthritis-induced osteoporosis
| Autor: | Jingqiu Lu, Jianhua Xu, Shengqian Xu, Yu Wang |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Bone disease Bone density Immunology Osteoporosis Arthritis Rheumatoid Rheumatology Osteoprotegerin Osteoclast Bone Density Internal medicine medicine Immunology and Allergy Humans Femur Femoral neck Aged Lumbar Vertebrae biology business.industry RANK Ligand Middle Aged medicine.disease Radiography Endocrinology medicine.anatomical_structure RANKL biology.protein Female business |
| Zdroj: | Rheumatology international. 32(11) |
| ISSN: | 1437-160X |
| Popis: | Osteoporosis represents an important cause of morbidity in adult rheumatoid arthritis (RA) patients who exhibit increased fracture risk. It is thought that osteoclast and its dysfunction which mediated by many cytokines are the principal pathogenesis of this bone disease, although the mechanisms are still not fully understood. Osteoprotegerin (OPG) and receptor activator of nuclear factor-kappa B ligand (RANKL) have been revealed in the pathogenesis of primary osteoporosis and other metabolic bone diseases. Thus, the aim of this study was to investigate the possible role of the OPG/RANKL system in RA-related bone loss. A total of 64 Chinese patients with RA and 60 healthy control subjects were involved. Serum levels of OPG and RANKL were measured by ELISA. BMD of nondominant forearm, lumbar spine(L1–4) and proximal femur, including femoral neck, Wards triangle, greater trochanter were assessed using dual-energy X-ray absorptiometry. RA patients had a higher incidence of osteoporosis (23/64, 35.9%) than that in healthy controls (9/60, 15.0%) (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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