Chloramphenicol antibody causing interference in antibody detection and identification tests
| Autor: | S. T. Urbaniak, K. M. Beattie, P. J. Atherton, R. M. Barr, K. L. Burnie, S. J. Ferguson |
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| Rok vydání: | 1976 |
| Předmět: |
Adult
Male Immunology Antibodies Microbiology ABO Blood-Group System ABO blood group system medicine Immunology and Allergy Humans Bacteriostatic agent biology Chemistry Chloramphenicol Antibody titer Hematology Middle Aged Virology Red blood cell Agglutination (biology) Titer medicine.anatomical_structure biology.protein Immunologic Techniques Blood Banks Female Indicators and Reagents Antibody medicine.drug |
| Zdroj: | Transfusion. 16(2) |
| ISSN: | 0041-1132 |
| Popis: | Investigation of the serum of three patients with positive antibody detection tests demonstrated the cause in each to be an antibody against chloramphenicol, a bacteriostatic agent used in commercial red blood cell reagents. Washing of these red cells prior to use prevented agglutination. All three examples of anti-chloramphenicol antibody were IgM and were in low titer when tested at room temperature and 37 C in saline. Two of the antibodies bound complement. The possibility of an antibody to an ingredient of the commercial preservative solution should be considered if problems are encountered in tests with unwashed commercial red blood cell reagents. |
| Databáze: | OpenAIRE |
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