Autoantibodies to Cryptic Epitopes of C-Reactive Protein and other Acute Phase Proteins in the Toxic Oil Syndrome
| Autor: | Gus Khursigara, Terry W. Du Clos, Juan J. Picazo, Susanne A. Bell, Robert L. Rubin |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Protein Denaturation
Immunology Brassica Cross Reactions Biology Fibrinogen Autoantigens Epitope Autoimmune Diseases Fatty Acids Monounsaturated Epitopes medicine Plant Oils Immunology and Allergy Autoantibodies Autoimmune disease Aniline Compounds Poisoning Autoantibody Acute-phase protein Ceruloplasmin medicine.disease C-Reactive Protein Spain alpha 1-Antitrypsin Chronic Disease Humoral immunity biology.protein Rapeseed Oil Antibody Toxic oil syndrome Acute-Phase Proteins medicine.drug |
| Zdroj: | Journal of Autoimmunity. 8:293-303 |
| ISSN: | 0896-8411 |
| DOI: | 10.1006/jaut.1995.0022 |
| Popis: | Toxic oil syndrome (TOS) was caused by the consumption of rapeseed oil contaminated with derivatives of aniline. Many persons who survived the acute phase developed a puzzling, multi-year chronic disease considered to be inflammatory or autoimmune in nature. In attempting to characterize their autoantibodies, we found that 74% of TOS patients with chronic disease had IgG antibodies to C-reactive protein (CRP). This activity was detectable only when CRP was chemically or physically denatured and behaved like a previously described antibody produced by immunization with the CRP monomer. Significant antibody reactivities to other acute phase proteins, especially alpha 1-antitrypsin and fibrinogen (P0.025) and ceruloplasmin (P0.05) were also observed. IgG antibodies to cryptic epitopes in CRP and other major serum proteins that increase during the acute phase response may reflect an earlier toxin-mediated insult to the liver that included abnormal biosynthesis of and/or damage to acute phase proteins. |
| Databáze: | OpenAIRE |
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