Treatment patterns and clinical outcomes of palbociclib-based therapy received in US community oncology practices
| Autor: | Junji Lin, Maxine D. Fisher, Lynn McRoy, Mark S. Walker, Cralen Davis, Nan Hu, Debanjali Mitra |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Pyridines medicine.drug_class Breast Neoplasms Palbociclib Piperazines 03 medical and health sciences 0302 clinical medicine Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans In patient 030212 general & internal medicine Fulvestrant Protein Kinase Inhibitors Survival rate Aged Retrospective Studies Aged 80 and over Aromatase inhibitor Aromatase Inhibitors business.industry Medical record Retrospective cohort study General Medicine Middle Aged medicine.disease Metastatic breast cancer Progression-Free Survival United States Survival Rate Receptors Estrogen 030220 oncology & carcinogenesis Female Receptors Progesterone business medicine.drug |
| Zdroj: | Future Oncology. 17:1001-1011 |
| ISSN: | 1744-8301 1479-6694 |
| DOI: | 10.2217/fon-2020-0744 |
| Popis: | Background: Limited studies have evaluated palbociclib-based therapy use in patients with advanced/metastatic breast cancer in the real world. This retrospective study used medical records from US community oncology practices to address the gap. Materials & methods: Eligible patients receiving palbociclib-based therapy per label indication from 3 February 2015 to 31 December 2017 were included. Descriptive analyses were conducted for patient characteristics, treatment patterns and clinical outcomes. Results: The study included 233 patients who received palbociclib + aromatase inhibitor (P+AI) and 48 who received palbociclib + fulvestrant (P+F). Real-world progression-free rate for P+AI was 69.8% (46.8%) at 12 (24) months (P+F: 43.5% [39.9%]) months. Real-world survival rate was 89.8% (71.4%) at 12 (24) months (P+F: 76.3% [65.0%]). Conclusion: The study findings are consistent with previous studies of palbociclib-based therapy. |
| Databáze: | OpenAIRE |
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