Diagnostic challenge in diagnosing bilateral breast metastases from mediastinal neuroendocrine tumor: A case report
| Autor: | Firdaus Hayati, Sugunah Sallapan, Kheng Hooi Chan, Siti Zubaidah Sharif, Chang Haur Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Adjuvant chemotherapy medicine.medical_treatment Case Report 03 medical and health sciences 0302 clinical medicine Neuroendocrine tumours medicine Mediastinal neoplasms Superior vena cava syndrome business.industry Disease progression Imaging study General Medicine Mediastinal Neoplasm Radiation therapy 030220 oncology & carcinogenesis Immunohistochemistry Diagnostic imaging 030211 gastroenterology & hepatology Surgery Histopathology Radiology medicine.symptom Breast neoplasms business |
| Zdroj: | Annals of Medicine and Surgery |
| ISSN: | 2049-0801 |
| Popis: | Background Metastatic neuroendocrine tumours (NETs) to the breast are very rare entities. Case presentation A 26-year-old lady presented with anterior neck swelling with symptoms of superior vena cava syndrome for 6 months. Imaging study revealed a mediastinal mass which was preceded with core biopsy which was consistent with high-grade small cell NETs. Despite second-line adjuvant chemotherapy and radiotherapy, her disease became advanced which was confirmed via restaging scan. There were bilateral breast lesions discovered during the scan which was deemed to be metastatic NETs histologically. Despite prompt initiation of treatment, she succumbed 1 year after the radiotherapy due to disease progression. Conclusion High suspicion of an index is needed for diagnosis when patients with known primary NETs present with suspicious breast lesions. Triple assessment is mandatory, however histopathology assessment and immunohistochemistry staining are the mainstay of diagnosis. Highlights • Metastatic breast neuroendocrine tumours are very rare entities especially when they arise from the mediastinum. • High suspicion of an index is needed for diagnosis when patients with known primary neuroendocrine tumours presented with suspicious breast lesions. • Any breast pathology requires a triple assessment including secondary breast neuroendocrine tumours. |
| Databáze: | OpenAIRE |
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