Glucosamine-Conjugated Nanoparticles for the Separation of Insulin-Secreting Beta Cells
| Autor: | Yuangang Zheng, Jackie Y. Ying, Nandanan Erathodiyil, Karthikeyan Narayanan, Andrew C.A. Wan, Alex W. H. Lin |
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| Rok vydání: | 2013 |
| Předmět: |
Materials science
Cell Biomedical Engineering Pharmaceutical Science Peptide Cell Separation Cell Line Biomaterials Mice chemistry.chemical_compound Glucosamine Insulin-Secreting Cells Quantum Dots medicine Animals Moiety Fluorescent Dyes Glucose Transporter Type 2 chemistry.chemical_classification Artificial cell Fibroblasts Small molecule medicine.anatomical_structure chemistry Biochemistry Nanoparticles Beta cell Peptides Iron oxide nanoparticles Protein Binding |
| Zdroj: | Advanced Healthcare Materials. 2:1198-1203 |
| ISSN: | 2192-2640 |
| DOI: | 10.1002/adhm.201200479 |
| Popis: | A small molecule, glucosamine, is used as targeting moiety for insulin-secreting beta cell separation in artificial cell mixtures and tissue samples. The specificity of glucosamine allows it to be used in cell sorting applications. In addition, a thrombin-specific cleavable peptide was used as an intermediary to release nanoparticles from cell surfaces to facilitate cell attachment and proliferation. |
| Databáze: | OpenAIRE |
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