Effects of age and disc area on optical coherence tomography measurements and analysis of correlations between optic nerve head and retinal nerve fibre layer
| Autor: | Sheng-Yao Hsu, Ming-Shien Chang, Mei-Lan Ko, George Linn, Rong-Kung Tsai, Min-Muh Sheu |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent genetic structures Nerve fibre Optic Disk Nerve fibre layer Optic cup (anatomical) chemistry.chemical_compound Nerve Fibers Optical coherence tomography Ophthalmology medicine Humans Child Aged medicine.diagnostic_test business.industry Age Factors Retinal Anatomy Middle Aged eye diseases Cross-Sectional Studies medicine.anatomical_structure chemistry Neuroretinal rim Optic nerve sense organs business Tomography Optical Coherence Retinal Neurons Optometry Optic disc |
| Zdroj: | Clinical and Experimental Optometry. 95:427-431 |
| ISSN: | 1444-0938 0816-4622 |
| DOI: | 10.1111/j.1444-0938.2012.00765.x |
| Popis: | Background The aim here was to investigate whether optic nerve head (ONH) parameters or retinal nerve fibre layer (RNFL) thickness correlate with age or disc area and whether the neuroretinal rim correlates with RNFL thickness. Methods This cross-sectional study enrolled 133 healthy subjects and analysed one randomly selected eye of each subject. All measurements of ONH parameters (including neuroretinal rim, disc and cup areas and cup-to-disc ratios) and RNFL thickness (global and quadrants) were taken by a single experienced operator using optical coherence tomography (OCT). Results Of the rim parameters analysed, average nerve width (the height of the nerve fibre bundle) was independent of age or disc area (p > 0.05). Disc area correlated positively with cup area (p 0.05). Of the RNFL thickness measurements analysed, temporal RNFL was independent of both age and disc area (p > 0.05). According to the analysis of the correlation between RNFL thickness and neuroretinal rim, global or non-temporal RNFL correlated positively with horizontal integrated rim width (p 4.000) and temporal RNFL was independent of all rim parameters (p > 0.05, F < 4.000). Conclusion Aging effect on neuroretinal rim loss or RNFL thickness change is non-uniform, and age is not a constant confounder when using OCT. The temporal RNFL is independent of age, disc area and neuroretinal rim. |
| Databáze: | OpenAIRE |
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