Eicosanoid production and cell accumulation induced by intrapleural injection of sodium arachidonate in the rat. Characterization of the model
| Autor: | E. C. Arner, W. Galbraith, K R Gans, S. R. Lundy, R. L. Dowling, Deborah A. Munzer |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Neutrophils Cell Count Arachidonic Acids Pharmacology Phenidone Leukotriene B4 Biochemistry chemistry.chemical_compound Lipoxygenase Edema Hydroxyeicosatetraenoic Acids medicine Animals Cyclooxygenase Inhibitors Lipoxygenase Inhibitors Pleurisy Arachidonate 5-Lipoxygenase Arachidonic Acid L-Lactate Dehydrogenase biology Chemistry Macrophages Rats Inbred Strains Rats Prostaglandin-Endoperoxide Synthases Enzyme inhibitor biology.protein Eicosanoids Pleura Arachidonic acid Cyclooxygenase medicine.symptom Glucocorticoid medicine.drug Eicosanoid Production |
| Zdroj: | Biochemical Pharmacology. 38:4151-4154 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/0006-2952(89)90698-9 |
| Popis: | Intrapleural injection of sodium arachidonate to rats produced both a cellular response and the generation of hydroxy fatty acid metabolites of arachidonic acid without edema. The cellular influx was inhibited by mixed 5-lipoxygenase/cyclooxygenase inhibitors and by a glucocorticoid but not by cyclooxygenase inhibitors. These results suggest that a model using intrapleural injection of sodium arachidonate may have utility for detecting systemically active 5-lipoxygenase inhibitors |
| Databáze: | OpenAIRE |
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