Insulin secretion, nutritional status and respiratory function in cystic fibrosis patients with normal glucose tolerance
| Autor: | Pier Maria Battezzati, Silvana Loi, Carla Colombo, Alberto Battezzati, Valentina Motta, Chiara Speziali, L. Claut, Gianfranco Alicandro |
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| Rok vydání: | 2011 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Vital capacity Adolescent Cystic Fibrosis medicine.medical_treatment Cystic fibrosis-related diabetes Nutritional Status Critical Care and Intensive Care Medicine Cystic fibrosis FEV1/FVC ratio Young Adult Diabetes mellitus Internal medicine Glucose Intolerance Insulin Secretion Medicine Humans Insulin Respiratory function Respiratory system Child Retrospective Studies Nutrition and Dietetics C-Peptide business.industry Respiration Fasting Glucose Tolerance Test medicine.disease Endocrinology Area Under Curve Linear Models Female business |
| Zdroj: | Clinical nutrition (Edinburgh, Scotland). 31(1) |
| ISSN: | 1532-1983 |
| Popis: | Impaired growth and nutritional status in CF may be related to progressive insulin deficiency before CF-Related Diabetes has established. Aim of this study was to analyse the association of circulating insulin with nutritional status and lung function in CF patients with normal glucose tolerance (NGT).We performed OGTT in 152 consecutive CF patients aged 8-20 years: 115 of them had NGT and were included in the study. Areas under the curves (AUC) of glucose, insulin and c-peptide after 120 min were calculated. Quartiles (Q) of increasing fasting insulin (fINS-Q) and c-peptide (fCP-Q) levels were calculated in CF patients. Respiratory function parameters (FEV1, FVC), Standard Deviation Scores (SDS) of height, weight and BMI were compared between Q1 and the three higher Q. Multiple regression analysis was used to analyse the association of fasting insulin, c-peptide or OGTT derived indices with nutritional or respiratory parameters.Compared to patients in fINS-Q4 or fCP-Q4, those in fINS-Q1 or in fCP-Q1 respectively showed lower levels of insulin AUC or c-peptide AUC (both P 0.0001), weight-SDS (P = 0.013, P = 0.007), BMI-SDS (P = 0.010, P = 0.002), FEV1 (P = 0.076, P = 0.013) and FVC (P = 0.101, P = 0.009). Age- and gender-adjusted regression analysis showed significant associations of fINS and fCP with SDS of BMI (P = 0.023 and P = 0.001 respectively), fCP was significant associated with FEV1 (P = 0.01). AUC insulin/AUC glucose ratio (P 0.0001) and AUC c-peptide/AUC glucose ratio (P = 0.0001) were significantly associated with FEV1.Insulin deficiency in CF patients with NGT has a significant impact on clinical outcomes. |
| Databáze: | OpenAIRE |
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