Increased Plasma Levels of Myosin Heavy Chain 11 Is Associated with Atherosclerosis
Autor: | Hirofumi Tomiyama, Lisa Takahashi, Masataka Taguri, Taishiro Chikamori, Koichiro Tasaki, Toshitaka Nagao, Jun Yamashita, Hiroyuki Kikuchi, Yuko Kato, Utako Yokoyama, Yoshihiro Ishikawa, Shigeru Inoue, Tomoaki Ishigami |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Disease 030204 cardiovascular system & hematology Article Coronary artery disease myosin heavy chain 03 medical and health sciences 0302 clinical medicine Internal medicine Myosin medicine Receiver operating characteristic business.industry biomarkers General Medicine Plasma levels medicine.disease smooth muscle cells atherosclerosis immunohistochemistry Coronary arteries 030104 developmental biology medicine.anatomical_structure Apoptosis Cardiology Medicine Immunohistochemistry business |
Zdroj: | Journal of Clinical Medicine; Volume 10; Issue 14; Pages: 3155 Journal of Clinical Medicine, Vol 10, Iss 3155, p 3155 (2021) Journal of Clinical Medicine |
ISSN: | 2077-0383 |
Popis: | Many studies have revealed numerous potential biomarkers for atherosclerosis, but tissue-specific biomarkers are still needed. Recent lineage-tracing studies revealed that smooth muscle cells (SMCs) contribute substantially to plaque formation, and the loss of SMCs causes plaque vulnerability. We investigated the association of SMC-specific myosin heavy chain 11 (myosin-11) with atherosclerosis. Forty-five patients with atherosclerosis and 34 control subjects were recruited into our study. In the atherosclerosis patients, 35 patients had either coronary artery disease (CAD) or peripheral artery disease (PAD), and 10 had both CAD and PAD. Coronary arteries isolated from five patients were subjected to histological study. Circulating myosin-11 levels were higher in the CAD or PAD group than in controls. The area under the receiver operating characteristic curve of myosin-11 was 0.954. Circulating myosin-11 levels in the CAD and PAD group were higher than in the CAD or PAD group, while high-sensitivity C-reactive protein concentrations did not differ between these groups. Multinomial logistic regression analyses showed a significant association of myosin-11 levels with the presence of multiple atherosclerotic regions. Myosin-11 was expressed in the medial layer of human atherosclerotic lesions where apoptosis elevated. Circulating myosin-11 levels may be useful for detecting spatial expansion of atherosclerotic regions. |
Databáze: | OpenAIRE |
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