Complete Gene Map of the Plastid-like DNA of the Malaria ParasitePlasmodium falciparum
| Autor: | D. H. Williamson, Daphne J. Moore, P. W. Moore, Malcolm Strath, Peter R. Preiser, Kaveri Rangachari, Roy A, Robert J.M. Wilson, Paul W. Denny, Roberts K, Whyte A |
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| Rok vydání: | 1996 |
| Předmět: |
Ribosomal Proteins
Erythrocytes Genes Protozoan Molecular Sequence Data Plasmodium falciparum Protozoan Proteins Biology chemistry.chemical_compound Structural Biology Ribosomal protein Transcription (biology) Animals Amino Acid Sequence Plastids RNA Messenger Amino Acids Plastid Molecular Biology Gene Conserved Sequence Genetics Base Composition Apicoplast Base Sequence Gene map fungi Chromosome Mapping food and beverages DNA Protozoan chemistry Transfer RNA Genome Protozoan Sequence Alignment RNA Protozoan DNA |
| Zdroj: | Journal of Molecular Biology. 261:155-172 |
| ISSN: | 0022-2836 |
| Popis: | Malaria parasites, and other parasitic protists of the Phylum Apicomplexa, carry a plastid-like genome with greatly reduced sequence complexity. This 35 kb DNA circle resembles the plastid DNA of non-photosynthetic plants, encoding almost exclusively components involved in gene expression. The complete gene map described here includes genes for duplicated large and small subunit rRNAs, 25 species of tRNA, three subunits of a eubacterial RNA polymerase, 17 ribosomal proteins, and a translation elongation factor. In addition, it codes for an unusual member of the Clp family of chaperones, as well as an open reading frame of unknown function found in red algal plastids. Transcription is polycistronic. This plastid-like DNA molecule is conserved in several genera of apicomplexans and is conjectured to have been acquired by an early progenitor of the Phylum by secondary endosymbiosis. The function of the organelle (plastid) carrying this DNA remains obscure, but appears to be specified by genes transferred to the nucleus. |
| Databáze: | OpenAIRE |
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