Bariatric Surgery-induced High-density Lipoprotein Functionality Enhancement Is Associated With Reduced Inflammation
| Autor: | Safwaan Adam, Jan H Ho, Yifen Liu, Tarza Siahmansur, Kirk Siddals, Zohaib Iqbal, Shazli Azmi, Siba Senapati, John New, Maria Jeziorska, Basil J Ammori, Akheel A Syed, Rachelle Donn, Rayaz A Malik, Paul N Durrington, Handrean Soran |
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| Rok vydání: | 2022 |
| Předmět: |
Inflammation
Aryldialkylphosphatase Tumor Necrosis Factor-alpha Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry Bariatric Surgery Biochemistry C-Reactive Protein Cholesterol Endocrinology Cardiovascular Diseases Humans Lipoproteins HDL ATP Binding Cassette Transporter 1 |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 107:2182-2194 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/clinem/dgac244 |
| Popis: | Background Emerging evidence suggests an association between impaired high-density lipoprotein (HDL) functionality and cardiovascular disease (CVD). HDL is essential for reverse cholesterol transport (RCT) and reduces inflammation and oxidative stress principally via paraoxonase-1 (PON1). RCT depends on HDL’s capacity to accept cholesterol (cholesterol efflux capacity [CEC]) and active transport through ATP-binding cassette (ABC) A1, G1, and scavenger receptor-B1 (SR-B1). We have studied the impact of Roux-en-Y gastric bypass (RYGB) in morbidly obese subjects on RCT and HDL functionality. Methods Biomarkers associated with increased CVD risk including tumour necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hsCRP), myeloperoxidase mass (MPO), PON1 activity, and CEC in vitro were measured in 44 patients before and 6 and 12 months after RYGB. Overweight but otherwise healthy (mean body mass index [BMI] 28 kg/m2) subjects acted as controls. Twelve participants also underwent gluteal subcutaneous adipose tissue biopsies before and 6 months after RYGB for targeted gene expression (ABCA1, ABCG1, SR-B1, TNF-α) and histological analysis (adipocyte size, macrophage density, TNF-α immunostaining). Results Significant (P Conclusion RYGB enhances HDL functionality in association with a reduction in adipose tissue and systemic inflammation. |
| Databáze: | OpenAIRE |
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