Ropivacaine 0.75% for extradural anaesthesia in elective caesarean section: an open clinical and pharmacokinetic study in mother and neonate
| Autor: | C. P. J. Morton, A. Magnusson, H. Jozwiak, J. H. Mcclure, S. Bloomfield |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Anesthesia Epidural medicine.medical_specialty medicine.drug_class Pharmacokinetics Pregnancy medicine Elective Cesarean Delivery Anesthesia Obstetrical Humans Medication Errors Ropivacaine Anesthetics Local Adverse effect Maternal-Fetal Exchange Cesarean Section business.industry Local anesthetic Hemodynamics Amides Surgery Open study Anesthesiology and Pain Medicine Elective Surgical Procedures Anesthesia Plasma concentration Anesthesia Intravenous Female Elective caesarean section business medicine.drug |
| Zdroj: | British Journal of Anaesthesia. 79:3-8 |
| ISSN: | 0007-0912 |
| DOI: | 10.1093/bja/79.1.3 |
| Popis: | In an open study we have investigated the efficacy of 20 ml of 0.75% ropivacaine (7.5 mg ml-1) to provide extradural anaesthesia for elective Caesarean section. Plasma concentrations (total and free) were estimated in the mother and neonate. Anaesthesia was effective and safe. Plasma concentrations of ropivacaine in the mother and neonate were within safe limits and consistent with previous studies. Two mothers received accidental i.v. injections of ropivacaine 75 mg and 150 mg, respectively, without serious adverse effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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