Characterization and evaluation of liver fibrosis grade in patients with chronic hepatitis B virus infection and normal transaminases
| Autor: | Casado Martín Marta, San Juan López Cristina, González Sánchez Mercedes, Vega Sáenz Jose Luis, Parrón Carreño Tesifón, Porcel Martín Almudena, Hernández Martínez Álvaro |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Hepatitis B virus hepatitis b e antigens Liver fibrosis Gastroenterology Severity of Illness Index Serology Transaminase Body Mass Index 03 medical and health sciences 0302 clinical medicine Hepatitis B Chronic Fibrosis Internal medicine chronic hepatitis b virus infection Epidemiology medicine Humans lcsh:RC799-869 Molecular Biology Transaminases Retrospective Studies Hepatology business.industry Retrospective cohort study Middle Aged medicine.disease Classification Logistic Models Editorial 030220 oncology & carcinogenesis DNA Viral Elevated transaminases Elasticity Imaging Techniques 030211 gastroenterology & hepatology lcsh:Diseases of the digestive system. Gastroenterology Female business Transient elastography Elastography Body mass index |
| Zdroj: | Clinical and Molecular Hepatology Clinical and Molecular Hepatology, Vol 24, Iss 4, Pp 384-391 (2018) |
| ISSN: | 2287-285X |
| Popis: | Backgrounds/Aims: The objective of our study was to determine the epidemiological, laboratory, and serological characteristics of patients with chronic hepatitis B virus (HBV) infection and normal transaminases. The study also aimed to evaluate liver damage by measuring the liver fibrosis (LF) grade and to identify possible factors associated with the presence of fibrosis. Methods: A retrospective observational study was conducted in patients with chronic HBV infection and classified as inactive carriers or immune-tolerant. Epidemiological variables of age, sex, immigrant, alcohol consumption, and body mass index (BMI), as well as virological variables (HBV DNA) and transaminase level were collected throughout the follow-up. The LF grade was evaluated by transient elastography. The cutoff value for significant fibrosis (SF) was liver stiffness ≥7.9 kPa. Results: A total of 214 patients were included in the analysis, and 62% of them had a BMI ≥25 kg/㎡. During follow-up, 4% of patients showed transaminase elevation ( |
| Databáze: | OpenAIRE |
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