Tube Expansion Deformation Enables In Situ Synchrotron X-ray Scattering Measurements during Extensional Flow-Induced Crystallization of Poly l-Lactide Near the Glass Transition
| Autor: | Riccardo Miscioscia, Julia A. Kornfield, Giuseppe Pandolfi, Karthik Ramachandran, Giovanni De Filippo, Tiziana Di Luccio |
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| Přispěvatelé: | Di Luccio, T., Pandolfi, G., De Filippo, G., Miscioscia, R. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Materials science
Polymers and Plastics PLLA bioresorbable vascular scaffolds stretch blow molding biaxial elongation SAXS WAXS Biaxial elongation Bioresorbable vascular scaffolds Stretch blow molding 02 engineering and technology 030204 cardiovascular system & hematology Article law.invention lcsh:QD241-441 03 medical and health sciences 0302 clinical medicine lcsh:Organic chemistry law Crystallization Scattering Small-angle X-ray scattering X-ray General Chemistry 021001 nanoscience & nanotechnology Microstructure Synchrotron Bioresorbable vascular scaffold Deformation (engineering) 0210 nano-technology Glass transition Biomedical engineering |
| Zdroj: | Polymers, Vol 10, Iss 3, p 288 (2018) Polymers Polymers; Volume 10; Issue 3; Pages: 288 |
| Popis: | Coronary Heart Disease (CHD) is one of the leading causes of death worldwide, claiming over seven million lives each year. Permanent metal stents, the current standard of care for CHD, inhibit arterial vasomotion and induce serious complications such as late stent thrombosis. Bioresorbable vascular scaffolds (BVSs) made from poly L-lactide (PLLA) overcome these complications by supporting the occluded artery for 3-6 months and then being completely resorbed in 2-3 years, leaving behind a healthy artery. The BVS that recently received clinical approval is, however, relatively thick (~150 μm, approximately twice as thick as metal stents ~80 μm). Thinner scaffolds would facilitate implantation and enable treatment of smaller arteries. The key to a thinner scaffold is careful control of the PLLA microstructure during processing to confer greater strength in a thinner profile. However, the rapid time scales of processing (~1 s) defy prediction due to a lack of structural information. Here, we present a custom-designed instrument that connects the strain-field imposed on PLLA during processing to in situ development of microstructure observed using synchrotron X-ray scattering. The connection between deformation, structure and strength enables processing-structure-property relationships to guide the design of thinner yet stronger BVSs. © 2018 by the authors. |
| Databáze: | OpenAIRE |
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