A significant association of viral loads with corneal endothelial cell damage in cytomegalovirus anterior uveitis
| Autor: | Masaru Miyanaga, Norio Shimizu, Shigeru Kinoshita, Kazunori Miyata, Manabu Mochizuki, Sunao Sugita, Kazuichi Maruyama, Tomohiro Morio |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Human cytomegalovirus medicine.medical_specialty Corneal endothelium genetic structures Cytomegalovirus Eye Infections Viral Iridocyclitis Polymerase Chain Reaction Aqueous Humor Cellular and Molecular Neuroscience Cornea Ophthalmology medicine Humans Endotheliitis Aged business.industry Aqueous humour virus diseases Corneal Endothelial Cell Loss Middle Aged Viral Load Eye infection medicine.disease Virology eye diseases Sensory Systems medicine.anatomical_structure Cytomegalovirus Infections DNA Viral Female sense organs business Viral load Uveitis |
| Zdroj: | British Journal of Ophthalmology. 94:336-340 |
| ISSN: | 0007-1161 |
| DOI: | 10.1136/bjo.2008.156422 |
| Popis: | Aim The aim of the study was to investigate the correlation between the clinical manifestation and the cytomegalovirus (CMV) viral load in the aqueous humour of patients with CMV anterior uveitis. Methods Seven patients with CMV-associated iridocyclitis and four patients with CMV-associated corneal endotheliitis were enrolled. Presence of CMV, but not other human herpes viruses, was confirmed by multiplex polymerase chain reaction (PCR). Viral load was measured using real-time PCR. Clinical manifestations were examined using a slit-lamp microscope and ophthalmoscope, applanation tonometer and specular microscope. Results All 11 patients had unilateral recurrent anterior uveitis with high intraocular pressure and mutton fat keratic precipitates with pigmentation. Stromal oedema of the cornea was found in CMV-associated endotheliitis, but not in CMV-associated iridocyclitis patients. A significant corneal endothelium cell loss was recorded in all 11 patients with CMV-associated endotheliitis and iridocyclitis patients. High viral loads of CMV were detected in the aqueous humour of all 11 patients. A significant association was found between the corneal endothelial cell loss intensity and CMV viral load in the aqueous humour. Conclusion There is a significant correlation between the CMV viral load and corneal endothelial cell loss in both CMV-associated iridocyclitis and corneal endotheliitis. |
| Databáze: | OpenAIRE |
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