Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta)
| Autor: | Henri Georges Michel Justin Bertrand, Paul A. Flecknell, Isabel S. Glover, Stuart N. Baker, Joseph Adam Middleton |
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| Přispěvatelé: | Bertrand, Henri Georges Michel Justin [0000-0002-1082-8384], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
Alphaxalone
040301 veterinary sciences Short Report primate Pregnanediones 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Evoked Potentials Somatosensory medicine Animals Humans Ketamine neurosurgery Alfentanil General anaesthetic General Veterinary biology business.industry Motor Cortex 04 agricultural and veterinary sciences biology.organism_classification Medetomidine Macaca mulatta Electric Stimulation Rhesus macaque medicine.anatomical_structure Somatosensory evoked potential Anesthesia Midazolam Animal Science and Zoology Female business somatosensory evoked potential 030217 neurology & neurosurgery medicine.drug Motor cortex |
| Zdroj: | Laboratory Animals |
| Popis: | This communication reports the effect of alphaxalone on motor somatosensory evoked potential (SEPs) in a rhesus macaque. The animal was deeply anaesthetised with an infusion of ketamine, medetomidine, midazolam and alfentanil. The median nerve was stimulated, and SEPs were recorded from the motor cortex. The successive administration of three doses of alphaxalone (0.5, 1 and 2 mg/kg) induced an increase of the latency time and a decrease of the amplitude of the SEPs. However, the structure of the waveforms was conserved, and hence alphaxalone might represent a suitable general anaesthetic option in neuroscience research as well as veterinary or human medicine. |
| Databáze: | OpenAIRE |
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