Axotomized bulbospinal neurons express c-Jun after cervical spinal cord injury
| Autor: | Pascale Boulenguez, Anne Kastner, Laurie Efthimiadi, Jean-Claude Stamegna, Patrick Gauthier, Stéphane Vinit |
|---|---|
| Přispěvatelé: | Lajard, Anne Marie |
| Rok vydání: | 2005 |
| Předmět: |
Stilbamidines
Proto-Oncogene Proteins c-jun Ventral respiratory group medicine.medical_treatment Central nervous system Cell Count Spinal cord injury Biology Functional Laterality Rats Sprague-Dawley medicine Animals [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Axon Spinal Cord Injuries Neurons Medulla Oblongata General Neuroscience c-Jun Axotomy Phospho-c-Jun medicine.disease Spinal cord Rats Medullary neurons medicine.anatomical_structure Gene Expression Regulation nervous system Female Neuron Raphe nuclei Neuroscience |
| Zdroj: | NeuroReport. 16:1535-1539 |
| ISSN: | 0959-4965 |
| Popis: | In several central nervous system neuronal populations, axotomy triggers the upregulation of regeneration-associated genes such as c-Jun, which determines neurons ability to regenerate axon in a growth-permissive environment. We analyzed the expression of c-Jun in rat ventral medullary neurons after cervical hemisection in order to investigate their intrinsic regenerative potential. Maximal expression of c-Jun was observed 7 days after injury mainly in axotomized medullary neurons located in the gigantocellularis nucleus, the raphe nucleus and, although less intensively, in the rostral ventral respiratory group. This suggests that after high cervical injury, a large number of medullary neurons projecting to the spinal cord become competent for axonal regeneration, although this regenerating potential may not be equivalent between the various neuronal populations. |
| Databáze: | OpenAIRE |
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