Somatic evolution and global expansion of an ancient transmissible cancer lineage

Autor: Ludmil B. Alexandrov, Janice L Allen, Maximilian R Stammnitz, Adrian Baez-Ortega, Ismail Thoya Ngoka, Yaghouba Kane, Katherine Polak, Debbie Koenig, Gabriele Marino, Inigo Martincorena, Berna Nakanwagi, Andrigo Barboza De Nardi, Joaquim Henriques, Mayra F Martínez-López, Artemio Castillo Domracheva, Cathy King, Thibault Losfelt, Kevin Gori, Young Mi Kwon, Ada Krupa, John F Reece, Antonio Ortega-Pacheco, Natalia Ignatenko, Alvaro S Wehrle-Martinez, Pagona G. Gouletsou, Sally J Nixon, Bogdan A. Viţălaru, Laura Delgadillo Keenan, Elizabeth M Tudor, Audrey E Steenland-Smit, Hugh R Cran, Sevil Atalay Vural, Marta Lanza-Perea, Leontine Bansse-Issa, Michael R. Stratton, Edward J. Migneco, Maria C. Peleteiro, Karina F de Castro, Michael C. Meyer, Eric Davis, Sheila K Schmeling, Adriana M Lopez Quintana, Elizabeth P. Murchison, Simón Martínez Castañeda, Olga Shamanova, Rodrigo dos Santos Horta, Jinhong Wang, Mihran Lazyan, Fanny Gallardo-Arrieta, Skye N Fruean, Karter B. Neal, Anna P de Vos, Jocelyn L Bisson, Alan G. Sherlock, Sophie A.E. Widdowson, Olga Glebova, Lester J. Tapia Martínez, Mohammed Fazil, Steven J. Kruzeniski, Cristian G. Torres, Oliver Walkinton, Ibikunle A Faramade, Winifred Neunzig, Jose Rojas Gutierrez, Adela R. Espinoza Huerta, Mirjam G van der Wel, Haleema Sadia, Edward M Donelan, Alla Svitich, Rodrigo F Häfelin Manrique, Thinlay N Bhutia, Eleni Fotopoulou, Karen M Allum, Francisco Pedraza-Ordoñez, Cristóbal Briceño, Ruth J. Pye, Máire Ní Leathlobhair, Jane T Crawford, Andrea Strakova, Anne M Corrigan
Přispěvatelé: Baez Ortega, Adrian [0000-0002-9201-4420], Gori, Kevin [0000-0001-7975-4275], Strakova, Andrea [0000-0001-6221-5515], Stammnitz, Maximillian [0000-0002-1704-9199], Murchison, Elizabeth [0000-0001-7462-8907], Apollo - University of Cambridge Repository, University of Cambridge, Animal Management in Rural and Remote Indigenous Communities (AMRRIC), World Vets, Stichting Dierenbescherming Suriname, Government of Sikkim, Easter Bush Campus, University of Chile, University of Panamá, St. George's University, Nakuru District Veterinary Scheme Ltd, Animal Medical Centre, UC Davis School of Veterinary Medicine, Centro Universitário de Rio Preto (UNIRP), Universidade Estadual Paulista (Unesp), Ladybrand Animal Clinic, Veterinary Clinic Sr. Dog's, World Vets Latin America Veterinary Training Center, National Veterinary Research Institute, Animal Clinic, Intermunicipal Stray Animals Care Centre (DIKEPAZ), Animal Protection Society of Samoa, University of Zulia, Veterinary Clinic BIOCONTROL, University of Thessaly, Hospital Veterinário Berna, Universidade Vila Velha, Veterinary Clinic Zoovetservis, École Inter-états des Sciences et Médecine Vétérinaires de Dakar, Utrecht University, Vetexpert Veterinary Group, Veterinary Clinic Lopez Quintana, Saint Gilles les Bains, University of Messina, Universidad Autónoma del Estado de México, Universidad de las Américas, Champalimaud Center for the Unknown, Touray and Meyer Vet Clinic, Hillside Animal Hospital, Kampala Veterinary Surgery, Asavet Veterinary Charities, Vets Beyond Borders, Autonomous University of Yucatan, Universidad de Caldas, University of Lisbon, Four Paws International, Help in Suffering, Veterinary Clinic Dr José Rojas, Engineering and Management Sciences, Corozal Veterinary Clinic, Veterinary Clinic Vetmaster, State Hospital of Veterinary Medicine, Jomo Kenyatta University of Agriculture and Technology, University of Melbourne, Animal Anti Cruelty League, Faculty of Veterinary Medicine Bucharest, Ankara University, National University of Asuncion, Lilongwe Society for Protection and Care of Animals (LSPCA), Wellcome Sanger Institute, San Diego
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Baez-Ortega, A, Gori, K, Strakova, A, Allen, J L, Allum, K M, Bansse-Issa, L, Bhutia, T N, Bisson, J L, Briceño, C, Castillo Domracheva, A, Corrigan, A M, Cran, H R, Crawford, J T, Davis, E, de Castro, K F, B de Nardi, A, de Vos, A P, Delgadillo Keenan, L, Donelan, E M, Espinoza Huerta, A R, Faramade, I A, Fazil, M, Fotopoulou, E, Fruean, S N, Gallardo-Arrieta, F, Glebova, O, Gouletsou, P G, Häfelin Manrique, R F, Henriques, J J G P, Horta, R S, Ignatenko, N, Kane, Y, King, C, Koenig, D, Krupa, A, Kruzeniski, S J, Kwon, Y-M, Lanza-Perea, M, Lazyan, M, Lopez Quintana, A M, Losfelt, T, Marino, G, Martínez Castañeda, S, Martínez-López, M F, Meyer, M, Migneco, E J, Nakanwagi, B, Neal, K B, Neunzig, W, Ní Leathlobhair, M, Nixon, S J, Ortega-Pacheco, A, Pedraza-Ordoñez, F, Peleteiro, M C, Polak, K, Pye, R J, Reece, J F, Rojas Gutierrez, J, Sadia, H, Schmeling, S K, Shamanova, O, Sherlock, A G, Stammnitz, M, Steenland-Smit, A E, Svitich, A, Tapia Martínez, L J, Thoya Ngoka, I, Torres, C G, Tudor, E M, van der Wel, M G, Viţălaru, B A, Vural, S A, Walkinton, O, Wang, J, Wehrle-Martinez, A S, Widdowson, S A E, Stratton, M R, Alexandrov, L B, Martincorena, I & Murchison, E P 2019, ' Somatic evolution and global expansion of an ancient transmissible cancer lineage ', Science, vol. 365, no. 6452 . https://doi.org/10.1126/science.aau9923
Science (New York, N.Y.)
Science
Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Popis: Made available in DSpace on 2019-10-06T15:53:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-02 GPD Charitable Trust Leverhulme Trust The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by “metastasizing” between hosts through cell transfer. The somatic mutations in this cancer record its phylogeography and evolutionary history. We constructed a time-resolved phylogeny from 546 CTVT exomes and describe the lineage's worldwide expansion. Examining variation in mutational exposure, we identify a highly context-specific mutational process that operated early in the cancer's evolution but subsequently vanished, correlate ultraviolet-light mutagenesis with tumor latitude, and describe tumors with heritable hyperactivity of an endogenous mutational process. CTVT displays little evidence of ongoing positive selection, and negative selection is detectable only in essential genes. We illustrate how long-lived clonal organisms capture changing mutagenic environments, and reveal that neutral genetic drift is the dominant feature of long-term cancer evolution. Transmissible Cancer Group Department of Veterinary Medicine University of Cambridge Animal Management in Rural and Remote Indigenous Communities (AMRRIC) World Vets Animal Shelter Stichting Dierenbescherming Suriname Sikkim Anti-Rabies and Animal Health Programme Department of Animal Husbandry Livestock Fisheries and Veterinary Services Government of Sikkim Royal (Dick) School of Veterinary Studies Roslin Institute University of Edinburgh Easter Bush Campus ConserLab Animal Preventive Medicine Department Faculty of Animal and Veterinary Sciences University of Chile Corozal Veterinary Hospital University of Panamá St. George's University Nakuru District Veterinary Scheme Ltd Animal Medical Centre International Animal Welfare Training Institute UC Davis School of Veterinary Medicine Centro Universitário de Rio Preto (UNIRP) Department of Clinical and Veterinary Surgery São Paulo State University (UNESP) Ladybrand Animal Clinic Veterinary Clinic Sr. Dog's World Vets Latin America Veterinary Training Center National Veterinary Research Institute Animal Clinic Intermunicipal Stray Animals Care Centre (DIKEPAZ) Animal Protection Society of Samoa Faculty of Veterinary Science University of Zulia Veterinary Clinic BIOCONTROL Faculty of Veterinary Medicine School of Health Sciences University of Thessaly Veterinary Clinic El Roble Animal Healthcare Network Faculty of Animal and Veterinary Sciences University of Chile OnevetGroup Hospital Veterinário Berna Universidade Vila Velha Veterinary Clinic Zoovetservis École Inter-états des Sciences et Médecine Vétérinaires de Dakar Department of Small Animal Medicine Faculty of Veterinary Medicine Utrecht University Vetexpert Veterinary Group Veterinary Clinic Lopez Quintana Clinique Veterinaire de Grand Fond Saint Gilles les Bains Department of Veterinary Sciences University of Messina Facultad de Medicina Veterinaria y Zootecnia Universidad Autónoma del Estado de México School of Veterinary Medicine Universidad de las Américas Cancer Development and Innate Immune Evasion Lab Champalimaud Center for the Unknown Touray and Meyer Vet Clinic Hillside Animal Hospital Kampala Veterinary Surgery Asavet Veterinary Charities Vets Beyond Borders Faculty of Veterinary Medicine Autonomous University of Yucatan Laboratorio de Patología Veterinaria Universidad de Caldas Interdisciplinary Centre of Research in Animal Health (CIISA) Faculty of Veterinary Medicine University of Lisbon Four Paws International Help in Suffering Veterinary Clinic Dr José Rojas Department of Biotechnology Balochistan University of Information Technology Engineering and Management Sciences Corozal Veterinary Clinic Veterinary Clinic Vetmaster State Hospital of Veterinary Medicine Jomo Kenyatta University of Agriculture and Technology Laboratory of Biomedicine and Regenerative Medicine Department of Clinical Sciences Faculty of Animal and Veterinary Sciences University of Chile Faculty of Veterinary and Agricultural Sciences University of Melbourne Animal Anti Cruelty League Clinical Sciences Department Faculty of Veterinary Medicine Bucharest Department of Pathology Faculty of Veterinary Medicine Ankara University Faculty of Veterinary Sciences National University of Asuncion Lilongwe Society for Protection and Care of Animals (LSPCA) Wellcome Sanger Institute Department of Cellular and Molecular Medicine University of California San Diego Department of Clinical and Veterinary Surgery São Paulo State University (UNESP) Leverhulme Trust: 102942/Z/13/A
Databáze: OpenAIRE
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