18F-FDG PET/CT for identifying the potential causes and extent of secondary hemophagocytic lymphohistiocytosis

Autor: Ying Kan, Jacqui K Meeks, Daqing Ma, Leilei Yuan, Jigang Yang
Rok vydání: 2016
Předmět:
Adult
Male
Secondary Hemophagocytic Lymphohistiocytosis
medicine.medical_specialty
Adolescent
Physical examination
Still Disease
Multimodal Imaging
Lymphohistiocytosis
Hemophagocytic
030218 nuclear medicine & medical imaging
Nuclear Medicine and Molecular Imaging
Young Adult
03 medical and health sciences
0302 clinical medicine
Fluorodeoxyglucose F18
Positron Emission Tomography Computed Tomography
hemic and lymphatic diseases
medicine
Humans
Radiology
Nuclear Medicine and imaging
Medical history
Aged
Systemic lupus erythematosus
medicine.diagnostic_test
business.industry
Middle Aged
medicine.disease
Lymphoma
Positron emission tomography
030220 oncology & carcinogenesis
Female
Radiology
Radiopharmaceuticals
Differential diagnosis
Cardiology and Cardiovascular Medicine
Nuclear medicine
business
Zdroj: Diagnostic and Interventional Radiology. 22:471-475
ISSN: 1305-3612
1305-3825
DOI: 10.5152/dir.2016.15226
Popis: Purpose We aimed to evaluate the value of 18F-FDG positron emission tomography/computed tomography (PET/CT) for identifying the possible causes of secondary hemophagocytic lymphohistiocytosis (HLH). Methods Forty-five cases (17 female, 28 male; age, 17-79 years) with secondary HLH were included. The standard of reference for diagnosis in all patients was a combination of histology, clinical results (medical history, physical examination, and laboratory test results), and follow-up imaging for at least 12 months. All cases underwent 18F-FDG PET/CT to identify the possible trigger in HLH. Results Of 45 secondary HLH cases 10 (22.2%) were associated with infection, seven (15.6%) with rheumatic disease, and 28 (62.2%) with lymphoma. PET/CT images of 22 secondary HLH cases (48.9%) showed true positive results. PET/CT images demonstrated obvious tracer uptake in five of 10 secondary HLH cases with infection, one of three cases with lupus, two of two cases with rheumatoid arthritis, one of two cases with adult-onset Still disease, and 13 of 28 cases with lymphoma. Conclusion PET/CT is helpful for identifying the possible trigger (infection or malignant disease) and extent of secondary HLH. However, PET/CT alone is not sufficient to make a correct differential diagnosis.
Databáze: OpenAIRE
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