Association of Isolated Congenital Heart Disease with Fetal Brain Maturation
Autor: | Jane W. Newburger, Caitlin K. Rollins, David Wypij, Cynthia M. Ortinau, Kevin G. Friedman, Christian Stopp, Simon K. Warfield, Judy A. Estroff, Edward Yang, Camilo Jaimes, Ali Gholipour, Wayne Tworetzky, Valerie Rofeberg |
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Rok vydání: | 2020 |
Předmět: |
Adult
Heart Defects Congenital Male medicine.medical_specialty Heart disease Intraclass correlation Germinal matrix Pediatrics 030218 nuclear medicine & medical imaging 03 medical and health sciences Fetus 0302 clinical medicine Pregnancy Prenatal Diagnosis Internal medicine Image Interpretation Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Prospective cohort study business.industry Infant Newborn Brain Reproducibility of Results Gestational age medicine.disease Magnetic Resonance Imaging Cardiology Gestation Female Neurology (clinical) business 030217 neurology & neurosurgery |
Zdroj: | AJNR Am J Neuroradiol |
ISSN: | 1936-959X 0195-6108 |
Popis: | BACKGROUND AND PURPOSE: Brain MRI of newborns with congenital heart disease show signs of immaturity relative to healthy controls. Our aim was to determine whether the semiquantitative fetal total maturation score can detect abnormalities in brain maturation in fetuses with congenital heart disease in the second and third trimesters. MATERIALS AND METHODS: We analyzed data from a prospective study of fetuses with and without congenital heart disease who underwent fetal MR imaging at 25–35 weeks’ gestation. Two independent neuroradiologists blinded to the clinical data reviewed and scored all images using the fetal total maturation score. Interrater reliability was evaluated by the intraclass correlation coefficient using the individual reader scores, which were also used to calculate an average score for each subject. Comparisons of the average and individual reader scores between affected and control fetuses and relationships with clinical variables were evaluated using multivariable linear regression. RESULTS: Data from 69 subjects (48 cardiac, 21 controls) were included. High concordance was observed between readers with an intraclass correlation coefficient of 0.98 (95% CI, 0.97–0.99). The affected group had significantly lower fetal total maturation scores than the control group (β-estimate, –0.9 [95% CI, –1.5 to –0.4], P = .002), adjusting for gestational age and sex. Averaged fetal total maturation, germinal matrix, myelination, and superior temporal sulcus scores were significantly delayed in fetuses with congenital heart disease versus controls (P |
Databáze: | OpenAIRE |
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